Methotrexate
| Abbrev Code: | MTX | ||
| Order Code: | LAB481 | Order Name: | Methotrexate Level |
| Synonyms: | Mexate | ||
| Methodology: | ARK homogeneous enzyme immunoassay | ||
| CPT Codes: | 80204 x1, 80204 x1 | ||
| Turnaround Time: | Performed and reported 24 hours/day | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 1 mL |
| Minimum\Peds Volume: | 0.4 mL |
| Container: | Purple (EDTA) protect from light Alternate Containers: Red (no gel) protect from light |
| Collection Instructions: | Test is light sensitive, therefore wrap collection tube in foil or paper towel immediately after collection. |
| Causes for Rejection: | Not protected from light. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 0.5 mL, 0.1 mL minimum into a light protected vial. Store in refrigerator.
UMMC East: Decant and add pre-printed "STAT MTX" label to the aliquot tube. |
| Shipping Instructions: | Ship at refrigerated temperature; protect from light and temperature extremes. |
| Stability: | 2 weeks refrigerated; samples may be stored frozen if limited to no more than 3 freeze-thaw cycles. |
| Test Performed at or Referral Lab | Chemistry (Roche-UMMC East, Roche-UMMC West) |
Interpretive
| Reference Range: | Following a 4-6 hour infusion:
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| Use: | Monitor therapeutic dosing and evaluate toxicity. Plasma levels peak at 1-2 h after oral dose and 30-60 m after I.V. dose. Half-life is approximately 3-4 h. |
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