Nortriptyline


Abbrev Code:NOTRP   
Order Code:LAB1158Order Name:Nortriptyline
Synonyms:Aventyl; Pamelor; Tricyclic Antidepressants; Allegron; Noritren; Norpress; Nortrilen; Sensoval
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80335 x1, 80335 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon, Wed, Fri; results are reported within 1-5 days.
Compliance:

This test uses a manufacturer labeled Analyte Specific Reagent (ASR) as the reagent providing the specificity of the assay. The test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Alternate Containers: Purple (EDTA)
Collection Instructions:
  • If amitriptyline is administered, order Amitriptyline and Nortriptyline.
  • Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.
Causes for Rejection:Whole blood. Gel separator tubes, light blue (citrate) or yellow (SPS or ACD solution).


Processing and Shipping

Specimen Processing:Separate serum or plasma from cells within 2 hours. Centrifuge and aliquot 1 mL, 0.5 mL minimum. Store at refrigerated temperature.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 5 days at room temperature; 2 weeks refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:0090074


Interpretive

Critical Range:Toxic: >500 ng/mL
Toxic concentrations may cause anticholinergic effects, cardiac abnormalities and seizures.
Therapeutic Range:50-150 ng/mL
Use:Optimize drug therapy and monitor patient adherence.


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