Tobramycin
| Abbrev Code: | TOBRA | ||
| Order Code: | LAB3777 | Order Name: | Tobramycin |
| Methodology: | Turbidimetric rate | ||
| CPT Codes: | 80200 x1 | ||
| Turnaround Time: | Performed and reported 24 hours/day. | ||
| Special Instructions: | Comment last dose information on request form. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL; pediatric patients only: 0.4 mL in green (lithium heparin, no gel) |
| Container: | Red (no gel), St Johns/St Joseph/Woodwinds-Green (lithium heparin, no gel) Alternate Containers: Green (lithium heparin, no gel), St Johns/St Joseph/Woodwinds - Red (no gel) |
| Collection Instructions: | Trough levels: Collect immediately prior to next dose. Peak levels: collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function. |
| Causes for Rejection: | Processed >2 hours after collection; sample not analyzed or frozen within 4 hours. Collection in a gel tube. |
Processing and Shipping
| Specimen Processing: | Process within 2 hours. Centrifuge and aliquot 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds). If assaying is delayed more than 4 hours, then aliquot and freeze the sample. |
| Shipping Instructions: | Ship on dry ice. |
| Stability: | Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides, causing falsely low results.
Stability is 4 hours at room temperature or refrigerated; 1 month frozen. |
| Test Performed at or Referral Lab | Chemistry (UMMC-East Bank, Lakes, Southdale, UMMC/UMMCH-West Bank, St. Joseph's) |
Interpretive
| Critical Range: | Greater than 16 mg/L for traditional dosing; Greater than 35 mg/L for single daily dosing |
| Therapeutic Range: | Trough <1 mg/L; Peak: 5.0-12.0 mg/L, depending on dosage. |
| Use: | Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult less than 30 y); 3-6 h (adult 30 y or greater); 4-8 h (neonate). |
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