Tobramycin


Abbrev Code:TOBRA   
Order Code:LAB3777Order Name:Tobramycin
Methodology:Roche: Homogeneous enzyme immunoassay
Vista: Turbidmetric rate
CPT Codes: 80200 x1, 80200 x1
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:Comment last dose information on request. Beta-lactam antibiotics and cephalosporrins will inactivate aminoglycosides causing falsely low results.
Associated Links:

Roche Go Live Schedule



Collection Instructions

Specimen:Blood
Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL; pediatric patients only: 0.4 mL in green (lithium heparin, no gel)
Collection Instructions:Chemistry Tests Containers Chart
Trough levels: Collect immediately prior to next dose. Peak levels: collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function.
Causes for Rejection:Processed >2 hours after collection; sample not analyzed or frozen within 4 hours. Collection in a gel tube.


Processing and Shipping

Specimen Processing:Process within 2 hours. Centrifuge and aliquot 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds). If assaying is delayed more than 4 hours, then aliquot and freeze the sample.  Cancel if patient is receiving beta lactam antibiotics or cephalosporins. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results.
Shipping Instructions:Ship on dry ice.
Stability:3 days refrigerated; 1 month frozen
Test Performed at or Referral Lab Chemistry  (Roche-UMMC East, Southdale, UMMC/UMMCH-West Bank)


Interpretive

Critical Range:
Roche >16 ug/mL for traditional dosing
Vista >16 mg/L for traditional dosing
Note: mg/L = ug/mL
Therapeutic Range:
  Trough Peak
Roche 0.5-2.0 ug/mL 6-10 ug/mL
Vista <1 mg/L 5.0-12.0 umg/L,
depending on dosage
Note: mg/L = ug/mL
Use:Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult less than 30 y); 3-6 h (adult 30 y or greater); 4-8 h (neonate).


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