Tobramycin
Abbrev Code: | TOBRA | ||
Order Code: | LAB3777 | Order Name: | Tobramycin |
Methodology: | Homogeneous enzyme immunoassay | ||
CPT Codes: | 80200 x1, 80200 x1 | ||
Turnaround Time: | Performed and reported 24 hours/day. | ||
Special Instructions: | Comment last dose information on request. Beta-lactam antibiotics and cephalosporrins will inactivate aminoglycosides causing falsely low results. |
Collection Instructions
Specimen: | Blood |
Optimal Volume: | 2.5 mL |
Minimum\Peds Volume: | 0.6 mL; pediatric patients only: 0.4 mL |
Container: | Red (no gel) Alternate Containers: Purple (EDTA) |
Collection Instructions: | Trough levels: Collect immediately prior to next dose. Peak levels: collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function. |
Causes for Rejection: | Processed >2 hours after collection; sample not analyzed or frozen within 4 hours. Collection in a gel tube. |
Processing and Shipping
Specimen Processing: | Process within 2 hours. Centrifuge and aliquot 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds). If assaying is delayed more than 4 hours, then aliquot and freeze the sample. Cancel if patient is receiving beta lactam antibiotics or cephalosporins. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results. |
Shipping Instructions: | Ship on dry ice. |
Stability: | 3 days refrigerated; 1 month frozen |
Test Performed at or Referral Lab | Chemistry (Roche-UMMC East) |
Interpretive
Critical Range: | >16 ug/mL for traditional dosing
Note: mg/L = ug/mL |
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Therapeutic Range: |
Note: mg/L = ug/mL |
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Use: | Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult less than 30 y); 3-6 h (adult 30 y or greater); 4-8 h (neonate). |
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