Theophylline Level

Abbrev Code:THEO   
Order Code:LAB35Order Name:Theophylline Level
Synonyms:Aminophylline; Somophylline; Theo-Dur; Theolair; Theospan
Methodology:Kinetic interaction of microparticles in a solution (KIMS)
CPT Codes: 80198 x1
Turnaround Time:Performed and reported 24 hours/day. UMMC-East samples are sent to UMMC-West for testing.

Collection Instructions

Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Container:Green (lithium heparin, no gel)
Alternate Containers: Red (no gel)
Collection Instructions:Trough level is preferred; collect immediately prior to dose. Optimal sampling time for a peak level after oral dosage is 1-2 hours for fast release preparation and 4-6 hours post dose for slow release preparation. Optimal re-sampling time after change in dosage is 24-48 hours. Optimal sampling time for intravenous infusion is prior to infusion, 30 minutes after completion of loading dose, 4-6 hours after beginning therapy, 12-18 hours after beginning therapy and then repeat as necessary to evaluate therapy.
Patient Preparation:Intake of caffeine should be avoided because caffeine is metabolized to theophylline.

Processing and Shipping

Specimen Processing:Centrifuge and transfer serum/plasma within 2 hours of collection. Aliquot 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Chemistry  (Roche-Range, Roche-UMMC West)


Critical Range:Greater than 25 ug/mL
Therapeutic Range:10-20 ug/mL; for apnea of prematurity (gestational age less than 38 weeks) = 6-14 ug/mL
Use:Monitor therapeutic dosing and evaluate toxicity. Half-life is 3-8 h (adult); 1-8 h (child), and 12-60 h (neonate).

Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
[email protected] for TestID: 1480"