Theophylline
| Sunquest Code: | THEO | ||
| Epic Code: | LAB35 | Epic Name: | Theophylline Level |
| Synonyms: | Aminophylline; Somophylline; Theo-Dur; Theolair; Theospan | ||
| Methodology: | Turbidimetric rate | ||
| Turnaround Time: | Southdale and UMMC-West are performed and reported 24 hours/day; other sites are reported daily. Turnaround time is 2 hours for ER and stat requests. UMMC-East samples are sent to UMMC-West for testing. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL |
| Container: | Green (lithium heparin, gel), St. Johns - Green (lithium heparin, no gel) (Green (lithium heparin) on ICE, Red (no gel), Red or gold (gel), St. Johns - Red (no gel)) |
| Collection Instructions: | Trough level is preferred; collect immediately prior to dose. Optimal sampling time for a peak level after oral dosage is 1-2 hours for fast release preparation and 4-6 hours post dose for slow release preparation. Optimal re-sampling time after change in dosage is 24-48 hours. Optimal sampling time for intravenous infusion is prior to infusion, 30 minutes after completion of loading dose, 4-6 hours after beginning therapy, 12-18 hours after beginning therapy and then repeat as necessary to evaluate therapy. |
| Patient Preparation: | Intake of caffeine should be avoided because caffeine is metabolized to theophylline. |
Processing and Shipping
| Specimen Processing: | Centrifuge and transfer serum/plasma within 2 hours of collection. Aliquot 1.25 mL, 0.2 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Test Performed at or Referral Lab | Chemistry (Range, Southdale, UMMC/UMMCH-West Bank, St. John's) |
Interpretive
| Critical Range: | Greater than 25 mg/L |
| Therapeutic Range: | 10-20 mg/L; for apnea of prematurity (gestational age less than 38 weeks) = 6-14 mg/L |
| Use: | Monitor therapeutic dosing and evaluate toxicity. Half-life is 3-8 h (adult); 1-8 h (child), and 12-60 h (neonate). |
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