Valproic Acid
| Abbrev Code: | VAL | ||
| Order Code: | LAB25 | Order Name: | Valproic Acid |
| Order Instructions: | If LAB5847-Valproic Acid, Free and Total is ordered at the same time, this test will not be performed in-house. | ||
| Synonyms: | Depakene; Depakote; Dipropylacetic Acid | ||
| Methodology: | Homogeneous enzyme immunoassay | ||
| CPT Codes: | 80164 x1, 80164 x1 | ||
| Turnaround Time: | Performed and reported 24 hours/day. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL |
| Container: | Red (no gel) Alternate Containers: Purple (EDTA) |
| Collection Instructions: | Trough level is preferred; collect immediately prior to next dose. Collect peak level 30-60 minutes after a single dose of syrup; 2-8 hours after capsules or tablets. |
| Causes for Rejection: | Results may be altered if collected in gel tube. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot within 2 hours of collection 1.25 mL, 0.2 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | 2 days at room temperature; 7 days refrigerated; 3 months frozen. |
| Test Performed at or Referral Lab | Chemistry (Roche-Grand Itasca, Roche-Lakes, Roche-Northland, Roche-Range, Roche-Ridges, Roche-Southdale, Roche-St. John's, Roche-UMMC East) |
Interpretive
| Critical Range: | Greater than 150 ug/mL |
| Therapeutic Range: | 50-100 ug/mL; epilepsy and mania patients: 50-125 ug/mL; some patients require and can tolerate values up to 150 ug/mL. |
| Use: | Half-life: <2 months: 6.5 hours; children: 6-15 hours; adults: 8-15 hours |
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