Valproic Acid

Abbrev Code:VAL   
Order Code:LAB25Order Name:Valproic Acid
Order Instructions:If LAB5847-Valproic Acid, Free and Total is ordered at the same time, this test will not be performed in-house.
Synonyms:Depakene; Depakote; Dipropylacetic Acid
Methodology:Roche: Homogeneous enzyme immunoassay

Vista: Turbidmetric rate
CPT Codes: 80164 x1, 80164 x1
Turnaround Time:Performed and reported 24 hours/day.
Associated Links:

Roche Go Live Schedule

Collection Instructions

Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Collection Instructions:Chemistry Tests Containers Chart
Trough level is preferred; collect immediately prior to next dose. Collect peak level 30-60 minutes after a single dose of syrup; 2-8 hours after capsules or tablets.
Causes for Rejection:Results may be altered if collected in gel tube.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Roche: 2 days at room temperature; 7 days refrigerated; 3 months frozen.
Vista: 2 hours at room temperature; 8 hours refrigerated; 2 months frozen.
Test Performed at or Referral Lab Chemistry  (Roche-Grand Itasca, Roche-Lakes, Roche-Northland, Roche-Range, Roche-Ridges, Roche-Southdale, Roche-St. John's, Roche-UMMC East, UMMC/UMMCH-West Bank)


Critical Range:Greater than 150 mg/L
Therapeutic Range:50-100 mg/L; epilepsy and mania patients: 50-125 mg/L; some patients require and can tolerate values up to 150 mg/L.
Use:Half-life: <2 months: 6.5 hours; children: 6-15 hours; adults: 8-15 hours

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