Oligoclonal Band Profile

Abbrev Code:OLIGO   
Order Code:LAB740Order Name:Oligoclonal Banding
Order Instructions:See aliquot list information for blood in separate listing. Do not order IGGSYN if OLIGO is ordered. IGGSYN is included in OLIGO.
Synonyms:IgG Index, Cerebrospinal Fluid; IgG Synthesis, Cerebrospinal Fluid
Methodology:Isoelectric focusing/Immunoturbidimetry
CPT Codes: 83916 x1, 82784 x4, 82040 x1, 82042 x1, 82784 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Sat; results are reported within 1-3 days.

Collection Instructions

Specimen:Blood and CSF
Optimal Volume:1.5 mL CSF and 2 mL blood
Minimum\Peds Volume:1 mL CSF and 1.4 mL blood
Container:Sterile tube, Red or gold (gel)
Alternate Containers: Red (no gel)
Collection Instructions:Collect CSF specimens in a sterile container, collect blood specmen in a red/black (gel) tube within 48 hours of CSF collection. Blood specimen must accompany CSF.
Causes for Rejection:Grossly bloody or hemolyzed specimens, or severe lipemia.

Processing and Shipping

Specimen Processing:Send serum (collected within 48 hours of CSF) with the CSF specmen. Centrifuge at room temperature.
CSF: Aliquot 1.5 mL, 1 mL minimum.
Serum: Aliquot 1 mL; 0.6 mL minimum.
Shipping Instructions:Ship on dry ice.
Stability:2 weeks refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80440


Reference Range:
IgG Serum 0-2 y: 242-1108 mg/dL
3-4 y: 485-1160 g/dL
5-9 y: 514-1672 mg/dL
10-14 y: 581-1652 mg/dL
15-18 y: 479-1433 mg/dL
19 y & older: 768-1632 mg/dL
IgG CSF 0-6.0 mg/dL
Albumin, Serum (NEPH) 3500-5200 mg/dL
Albumin CSF 0-35 mg/dL
Albumin Index 0.0-9.0
IgG Index 0.28-0.66
CSF, IgG/Albumin Ratio 0.09-0.25
CSF, Oligoclonal Bands Negative
CSF IgG Synthesis Rate ≤ 8.0 mg/d
Interpretation By report
CSF Oligoclonal Bands Number 0-1 bands
A patient is considered positive for CSF oligoclonal bands if here are two or more bands in the CSF immunoglobulin region that are not present in the serum.
Use:Diagnosis of diseases of the central nervous system including meningitis, tumor, syphilis, and multiple sclerosis.

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