Histoplasma capsulatum Antigen, Blood
| Sunquest Code: | HISTOP | ||
| Epic Code: | LAB3531 | Epic Name: | Histoplasma Agn Blood |
| Order Instructions: | See HISTPU for non-blood specimens. | ||
| Methodology: | Enzyme immunoassay | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Mon-Thur; results are reported within 2-3 days. | ||
| Special Instructions: | Patients should not have more than one serum histoplasma per 24 hours. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 4 mL |
| Minimum\Peds Volume: | 2.6 mL |
| Container: | Red (no gel) (Purple (EDTA), Red or gold (gel)) |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 2 mL, 1.2 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: |
14 days room temperature or refrigerated and indefinitely frozen.
|
| Test Performed at or Referral Lab | Lab Sendouts (MiraVista Diagnostics) |
| Referral Lab number: | 310 |
Interpretive
| Reference Range: | By report. |
| Limitations: | Heterophile antibodies and rheumatoid factor can cause positive interference. Cross reactions due to closely related antigenic epitopes are seen in patients with blastomycosis, paracoccidiodomycosis and penicilliosis. |
| Use: | Aid in the diagnosis of histoplasmosis by antigen detection. Measurement of antigen in urine offers the highest sensitivity for diagnosis of acute pulmonary or disseminated histoplasmosis. Testing bronchoalveolar lavage may improve the sensitivity for diagnosis of pulmonary histoplasmosis and CSF for diagnosis of meningitis. For monitoring therapy, testing both urine and serum offers the highest sensitivity. |
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