Sweat Chloride

Abbrev Code:SWECL   
Order Code:LAB1726Order Name:Sweat Chloride Analysis (Peds)
Synonyms:Cystic Fibrosis Sweat Test; Pilocarpine Iontophoresis
Methodology:Sweat stimulation by Pilocarpine iontophoresis; chloride by coulometric titration
CPT Codes: 89230 x1
Test Includes:Macroduct sweat collection: Sweat stimulation, collection, and chloride analysis.
Turnaround Time:Sweat Chlorides are scheduled and collected by the Acute Care Lab, Mon-Fri.
Special Instructions:To schedule outpatient collections, contact the Pediatric Specialty Clinic Call Center at 612-365-6777. To schedule inpatient collections, contact the Sweat Chloride Laboratory at 612-365-8053. 24 hour notice is required for inpatient scheduling requests.

Collection Instructions

Specimen:Fluid, sweat
Optimal Volume:75 uL
Minimum\Peds Volume:15 uL
Patient Preparation:Patient must be older than 48 hours of age or greater than 6.6 lbs (3 kg). Patient cannot be NPO or on diuretics prior to test.
Causes for Rejection:Insufficient sweat yield; less than 15 uL for the collection.

Processing and Shipping

Test Performed at or Referral Lab Lab Sendouts  (Sweat Chloride Lab-Discovery Clinic)


Reference Range:
Age Chloride (mmol/L)
All ages Less than 30: CF unlikely
30-59: Intermediate
Greater than or equal to 60: Indicative of CF
Repeat test is recommended when sweat collection weight below 15 mg if results are intermediate or screen and test results do not agree.
Use:Establish the diagnosis of cystic fibrosis. The test is useful in the evaluation of malabsorption, pancreatic insufficiency, history of meconium ileus and other problems of gastrointestinal tract, salt depletion syndrome, nasal polyps, aspermia, and chronic or recurrent lung disease, all of which may be symptoms of cystic fibrosis.

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