Nicotine and Cotinine, Confirmation, Urine
| Abbrev Code: | UNICNC | ||
| Order Code: | LAB1152 | Order Name: | Nicotine and Mets, Urn, Quant |
| Methodology: | Quantitative liquid chromatography/Tandem mass spectrometry | ||
| CPT Codes: | 80323 x1, 80323 x1 | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Sun-Sat; results are reported within 1-4 days. | ||
| Compliance: | This test uses a manufacturer labeled Analyte Specific Reagent (ASR) as the reagent providing the specificity of the assay. The test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Urine, random |
| Optimal Volume: | Submit entire collection; analysis requires 4 mL |
| Minimum\Peds Volume: | Submit entire collection; analysis requires 1 mL. |
| Container: | Plastic leakproof container, sterile |
| Causes for Rejection: | Specimens exposed to repeated freeze/thaw cycles. |
Processing and Shipping
| Specimen Processing: | Aliquot 4 mL, 1 mL minimum. Store at room temperature. |
| Shipping Instructions: | Ship at room temperature. |
| Stability: | 10 days at room temperature or refrigerated; 8 months frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 0092356 |
Interpretive
| Reference Range: |
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| Use: | For medical purposes only; not valid for forensic use.
This test is designed to evaluate recent use of nicotine-containing products. Passive and active exposure cannot be discriminated definitively, although a cutoff of 100 ng/mL cotinine is frequently used for surgery qualification purposes. For smoking cessation programs or compliance testing, the absence of expected drug(s) and/or metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Anabasine is included as a biomarker of tobacco use, versus nicotine replacement. Interpretive questions should be directed to the laboratory. |
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