Multiple Sclerosis Panel
| Abbrev Code: | OLIGO & MBPAN | ||
| Order Code: | LAB4909 & LAB190 | Order Name: | Send Outs Misc Test |
| Order Instructions: | Order both OLIGO and MBPAN | ||
| Synonyms: | OLIGO; LAB190; MBPAN; Protein Electrophoresis, CSF; CELP; ELP, Cerebrospinal Fluid; Oligoclonal Band Profile | ||
| Methodology: | Refer to individual test listings | ||
| CPT Codes: | 83873 x1, 83916 x1, 82784 x4, 82040 x1, 82042 x1, 82784 x1 | ||
| Test Includes: | Immunoglobulin G, CSF; IgG synthesis rate, CSF; IgG index; myelin basic protein, CSF; albumin, serum by nephelometry; albumin, CSF; albumin, index; Immunoglobulin G, serum; CSF IgG/Albumin Ratio, CSF Oligoclonal Bands | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days. | ||
Collection Instructions
| Specimen: | Blood and CSF |
| Optimal Volume: | 2 mL CSF and 2 mL blood |
| Minimum\Peds Volume: | 1.5 mL CSF and 1.2 mL blood |
| Container: | Red (no gel) Alternate Containers: Sterile tube, Red or gold (gel) |
| Collection Instructions: | Collect CSF specimen in a sterile container, collect blood specimen in a red/black top (gel) tube. Blood specimen must be collected within 48 hours of CSF. Specimens need to be assayed together for interpretation. |
| Causes for Rejection: | Hemolysis is associated with falsely elevated levels of MBP in the CSF. |
Processing and Shipping
| Specimen Processing: | Send serum, collected within 2 days of CSF, with the CSF specimen. Centrifuge at room temperature. CSF: aliquot 2 mL, 1.5 mL minimum; serum: 1 mL, 0.5 mL minimum. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing. Store in freezer. |
| Shipping Instructions: | Ship on dry ice. |
| Stability: | C&P order both OLIGO and MBPAN. If all available CSF is bloody, centrifuge the sample and separate from cells prior to freezing. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 80440 (OLIGO) and 80515 (MBP) |
Interpretive
| Reference Range: |
*For additional information refer to individual test. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum.
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| Use: | Diagnosis of diseases of the central nervous system including meningitis, tumor, syphilis, and multiple sclerosis. | |||||||||||||||||||||||||||||||||||||||
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