Multiple Sclerosis Panel

Abbrev Code:OLIGO & MBPAN   
Order Code:LAB4909 & LAB190Order Name:Send Outs Misc Test
Order Instructions:Order both OLIGO and MBPAN
Synonyms:OLIGO; LAB190; MBPAN; Protein Electrophoresis, CSF; CELP; ELP, Cerebrospinal Fluid; Oligoclonal Band Profile
Methodology:Refer to individual test listings
CPT Codes: 83873 x1, 83916 x1, 82784 x4, 82040 x1, 82042 x1, 82784 x1
Test Includes:Immunoglobulin G, CSF; IgG synthesis rate, CSF; IgG index; myelin basic protein, CSF; albumin, serum by nephelometry; albumin, CSF; albumin, index; Immunoglobulin G, serum; CSF IgG/Albumin Ratio, CSF Oligoclonal Bands
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.

Collection Instructions

Specimen:Blood and CSF
Optimal Volume:2 mL CSF and 2 mL blood
Minimum\Peds Volume:1.5 mL CSF and 1.2 mL blood
Container:Red (no gel)
Alternate Containers: Sterile tube, Red or gold (gel)
Collection Instructions:Collect CSF specimen in a sterile container, collect blood specimen in a red/black top (gel) tube. Blood specimen must be collected within 48 hours of CSF. Specimens need to be assayed together for interpretation.
Causes for Rejection:Hemolysis is associated with falsely elevated levels of MBP in the CSF.

Processing and Shipping

Specimen Processing:Send serum, collected within 2 days of CSF, with the CSF specimen. Centrifuge at room temperature. CSF: aliquot 2 mL, 1.5 mL minimum; serum: 1 mL, 0.5 mL minimum. If all available CSF is bloody, centrifuge the sample and separate supernatant from cells prior to freezing. Store in freezer.
Shipping Instructions:Ship on dry ice.
Stability:C&P order both OLIGO and MBPAN. If all available CSF is bloody, centrifuge the sample and separate from cells prior to freezing.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80440 (OLIGO) and 80515 (MBP)


Reference Range:
IgG Serum



0-2 y


3-4 y


5-9 y


10-14 y


15-18 y


≥19 y






0-6.0 mg/dL

Albumin, Serum (NEPH)

3500-5200 mg/dL

Albumin, CSF

0-35 mg/dL

Albumin Index


CSF, IgG Synthesis Rate

0.0-8.0 mg/d

IgG Index


CSF, IgG/Albumin Ratio


CSF Oligoclonal Bands #

0-1 Bands

Myelin Basic Protein

0.00-5.50 ng/mL


By report

*For additional information refer to individual test.

A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum.


Use:Diagnosis of diseases of the central nervous system including meningitis, tumor, syphilis, and multiple sclerosis.

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