Abbrev Code:MYO   
Order Code:LAB105Order Name:Myoglobin
CPT Codes: 83874 x1
Turnaround Time:Performed and reported 24 hours/day.

Collection Instructions

Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Container:Green (lithium heparin, gel)
Alternate Containers: Green (lithium heparin, no gel), Green (lithium heparin) on ICE, Green (sodium heparin, no gel), Red (no gel), Red or gold (gel)

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 2 hours of collection 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Stability: refrigerated - 7 days; frozen - 28 days.
Test Performed at or Referral Lab Chemistry  (Lakes, Southdale)


Reference Range:Less than 120 ug/L; values less than 120 ug/L 4 hours after onset of chest pain makes AMI unlikely
Use: Because myoglobin is found in high concentrations in myocardium, it is a sensitive but not specific marker of cardiac injury. Elevations can also occur due to skeletal muscle release or abnormal renal function (i.e., decreased clearance). Myoglobin should not be used for patients who have sustained traumas or had IM injections. Myoglobin is detectable 2 hours after coronary occlusion with peak levels occurring at 9-12 hours, and return to normal at 24-36 hours. Rapid clearance (half life = 8.9 ± 1.5 minutes) explains the rising and falling (staccato pattern) values observed in some patients with infarction, which most likely represents cyclical opening and closing of the infarct-related coronary artery. For this reason, a single negative myoglobin does not always exclude acute infarction.

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