Coccidioides Antibody by CF
| Abbrev Code: | CIAB | ||
| Order Code: | LAB3379 | Order Name: | Coccidioides Antibody |
| Synonyms: | Fungal Antibody, Coccidioides; Fungus; San Joaquin Fever; Valley Fever | ||
| Methodology: | Complement fixation | ||
| CPT Codes: | 86635 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported in 2-4 days. | ||
| Special Instructions: | Parallel testing is preferred. Label samples as acute or convalescent. Convalescent sample must be sent within 30 days of acute sample. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 1 mL |
| Container: | Red or gold (gel) Alternate Containers: Red (no gel) |
| Causes for Rejection: | Hemolyzed, icteric or lipemic specimens. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot ASAP or within 2 hours of collection, 1 mL, 0.4 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | After separation from cells: 48 hours at room temperature; 2 weeks refrigerated; 1 year frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 50170 |
Interpretive
| Reference Range: | Less than 1:2 titer
Any titer suggests past or current infection. However, greater than 30% of cases with chronic residual pulmonary disease have negative Compliment Fixation tests. Titers of less than 1:32 may indicate past infection or self-limited disease; anticoccidial CF antibody titers in excess of 1:16 may indicate disseminated infection, CF serology may be used to follow therapy. |
| Use: | CF measures both IgM and IgG. As single antibody titers are generally not diagnostic, paired samples are preferred. Acute and convalescent samples (drawn at least 21 days apart) showing at least a four-fold rise in titer, are diagnostic. |
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