Serotonin, Serum

Abbrev Code:SERO   
Order Code:LAB121Order Name:Serotonin
Methodology:High performance liquid chromatography
CPT Codes: 84260 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days.

For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Collection Instructions

Optimal Volume:1 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Patient Preparation:Abstain from medications for 72 hours prior to collection.
Causes for Rejection:Specimens other than serum, nonfrozen samples.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 1 hour of collection 0.5 mL; 0.2 mL minimum. Freeze immediately.
Shipping Instructions:Critical frozen. Separate specimens must be submitted when multiple tests are ordered.
Stability:After separation from cells: 24 hours refrigerated; 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:80397


Reference Range:50-220 ng/mL
Limitations:In general, EDTA whole blood (as compared to serum) preserved with ascorbic acid will give values most representative of blood concentrations. Most (95%) blood serotonin is found in platelets - refer to Serotonin, Whole Blood.
Use:Medications that may affect serotonin concentrations include lithium, MAO inhibitors, methyldopa, morphine, and reserpine. In general, foods that contain serotonin do not interfere significantly. Slight increases may be seen in acute intestinal obstruction, acute MI, cystic fibrosis, dumping syndromes, and nontropical sprue. Metastasizing abdominal carcinoid tumors often show serotonin concentrations greater than 400 ng/mL.

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