Amiodarone and Metabolite


Abbrev Code:AMIOD   
Order Code:LAB1148Order Name:Amiodarone Level
Synonyms:Cordarone; Desethylamiodarone; Cordarone; Nexterone; Pacerone
Methodology:Liquid chromatography/Tandem mass spectrometry (LC/MS/MS)
CPT Codes: 80151 x1, 80151 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Tues, Thur-Sat; results are reported within 1-4 days.
Compliance:

This test uses a manufacturer labeled Analyte Specific Reagent (ASR) as the reagent providing the specificity of the assay. The test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Alternate Containers: Purple (EDTA)
Collection Instructions:Timing of specimen collection: Pre-dose (trough) draw - at steady state concentration.
Causes for Rejection:Whole blood. Gel separator tubes, light blue (citrate) or yellow (SPS or ACD solution).


Processing and Shipping

Specimen Processing:Separate serum/plasma from cells within 2 hours of collection. Centrifuge and aliquot 1 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 1 month at room temperature; 6 weeks refrigerated or frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:0090161


Interpretive

Critical Range:Toxic: >3.0 μg/mL
Therapeutic Range:0.5-2.0 μg/mL
Use:Toxic concentrations may exacerbate arrhythmias, cause liver and lung toxicity, and thyroid dysfunction. The concentration of desethylamiodarone, an active major metabolite, is also reported but no therapeutic range is established. At steady state, the metabolite concentration is similar to the amiodarone concentration.


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