Clonazepam and Metabolite


Abbrev Code:CLONZM   
Order Code:LAB1218Order Name:Clonazepam and Metabolite
Synonyms:Klonopin
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80346 x1, 80346 x1
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; testing is performed Tue and Fri; results are reported within 1-5 days.
Compliance:

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Gray (sodium fluoride + potassium oxalate)
Alternate Containers: Green (sodium heparin, no gel), Purple (EDTA), Red (no gel)
Collection Instructions:Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Causes for Rejection:Collected in gel tube or in light blue (sodium citrate) tube. Hemolyzed specimens.


Processing and Shipping

Specimen Processing:Centrifuge and separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL, 1 mL minimum, serum or plasma.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 1 week at room temperature; 2 weeks refrigerated; 3 years frozen. (Avoid repeated freeze/thaw cycles). 
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:0090055


Interpretive

Critical Range:Toxic level: >80 ng/mL
Adverse effects may include drowsiness, headache, fatigue and ataxia.
Therapeutic Range:Dose-related range: 20-70 ng/mL - Dose (adult) 1-8 mg/d
Use:Optimize drug therapy and monitor patient adherence.


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