Lorazepam


Abbrev Code:LORA   
Order Code:LAB1226Order Name:Lorazepam Level
Synonyms:Ativan
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80346 x1, 80346 x1
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; testing is performed Tue and Fri. Results are reported within 1-5 days.
Compliance:

This test uses a standard method, which is universally applied across laboratories and has an established record of reliability and clinical validity.



Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Gray (sodium fluoride + potassium oxalate)
Alternate Containers: Green (sodium heparin, no gel), Purple (EDTA), Red (no gel)
Collection Instructions:Timing of specimen collection: Predose (trough) draw - At steady state concentration.
Causes for Rejection:Collected in gel or light blue (sodium citrate) tubes. Hemolyzed specimens.


Processing and Shipping

Specimen Processing:Centrifuge and separate from cells within 2 hours of collection. Aliquot 2 mL, 1.0 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 1 week at room temperature; 2 weeks refrigerated; 3 years frozen (avoid repeated freeze/thaw cycles).
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:0090181


Interpretive

Critical Range:Toxic level: >300 ng/mL.
Adverse effects may include respiratory depression, sedation, dizziness, weakness and lethargy.
Therapeutic Range:Dose related range: 50-240 ng/mL at dose (adult) of 1-10 mg/d.
Use:Optimize drug therapy and monitor patient adherence.


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