Lorazepam
| Abbrev Code: | LORA | ||
| Order Code: | LAB1226 | Order Name: | Lorazepam Level |
| Synonyms: | Ativan | ||
| Methodology: | Quantitative liquid chromatography/Tandem mass spectrometry | ||
| CPT Codes: | 80346 x1, 80346 x1 | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Sun-Sat; testing is performed Tue and Fri. Results are reported within 1-5 days. | ||
| Compliance: | This test uses a standard method, which is universally applied across laboratories and has an established record of reliability and clinical validity. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 4 mL |
| Minimum\Peds Volume: | 2.2 mL |
| Container: | Gray (sodium fluoride + potassium oxalate) Alternate Containers: Green (sodium heparin, no gel), Purple (EDTA), Red (no gel) |
| Collection Instructions: | Timing of specimen collection: Predose (trough) draw - At steady state concentration. |
| Causes for Rejection: | Collected in gel or light blue (sodium citrate) tubes. Hemolyzed specimens. |
Processing and Shipping
| Specimen Processing: | Centrifuge and separate from cells within 2 hours of collection. Aliquot 2 mL, 1.0 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | After separation from cells: 1 week at room temperature; 2 weeks refrigerated; 3 years frozen (avoid repeated freeze/thaw cycles). |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 0090181 |
Interpretive
| Critical Range: | Toxic level: >300 ng/mL.
Adverse effects may include respiratory depression, sedation, dizziness, weakness and lethargy. |
| Therapeutic Range: | Dose related range: 50-240 ng/mL at dose (adult) of 1-10 mg/d. |
| Use: | Optimize drug therapy and monitor patient adherence. |
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