Lorazepam
Abbrev Code: | LORA | ||
Order Code: | LAB1226 | Order Name: | Lorazepam Level |
Synonyms: | Ativan | ||
Methodology: | Quantitative liquid chromatography/Tandem mass spectrometry | ||
CPT Codes: | 80346 x1, 80346 x1 | ||
Turnaround Time: | Specimens are sent to the reference laboratory Sun-Sat; testing is performed Tue and Fri. Results are reported within 1-5 days. | ||
Compliance: | This test uses a standard method, which is universally applied across laboratories and has an established record of reliability and clinical validity. |
Collection Instructions
Specimen: | Blood |
Optimal Volume: | 4 mL |
Minimum\Peds Volume: | 2.2 mL |
Container: | Gray (sodium fluoride + potassium oxalate) Alternate Containers: Green (sodium heparin, no gel), Purple (EDTA), Red (no gel) |
Collection Instructions: | Timing of specimen collection: Predose (trough) draw - At steady state concentration. |
Causes for Rejection: | Collected in gel or light blue (sodium citrate) tubes. Hemolyzed specimens. |
Processing and Shipping
Specimen Processing: | Centrifuge and separate from cells within 2 hours of collection. Aliquot 2 mL, 1.0 mL minimum. Store in refrigerator. |
Shipping Instructions: | Ship at refrigerated temperature. |
Stability: | After separation from cells: 1 week at room temperature; 2 weeks refrigerated; 3 years frozen (avoid repeated freeze/thaw cycles). |
Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
Referral Lab number: | 0090181 |
Interpretive
Critical Range: | Toxic level: >300 ng/mL.
Adverse effects may include respiratory depression, sedation, dizziness, weakness and lethargy. |
Therapeutic Range: | Dose related range: 50-240 ng/mL at dose (adult) of 1-10 mg/d. |
Use: | Optimize drug therapy and monitor patient adherence. |
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