Abbrev Code:SERT   
Order Code:LAB1201Order Name:Sertraline
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80332 x1, 80332 x
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; testing is performed Wed, and results are reported within 1-8 days.

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Alternate Containers: Purple (EDTA), Pink (EDTA)
Collection Instructions:Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Causes for Rejection:Gel tubes, Whole blood, light blue citrate tubes or yellow ACD tubes.

Processing and Shipping

Specimen Processing:Centrifuge and separate serum or plasma from cells within 2 hours of collection. Aliquot 1 mL, 0.5 mL minimum, serum or plasma. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 24 hours at room temperature; 2 weeks refrigerated; 4 months frozen
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3005859


Critical Range:Toxic: >300 ng/mL
Reference Range:Not well established.
Sertraline doses ranging from 50-200 mg/d produce serum concentrations ranging from 30-200 ng/mL. Dosing above 200 mg/d is associated with increased adverse effects and decreased efficacy. Adverse effects may include dry mouth, headache, dizziness, somnolence, nausea and diarrhea.
Therapeutic Range:30-200 ng/mL

Sertraline doses range from 50-200 mg/day to produce serum concentration that range from 30-200 ng/mL. Dosing above 200 mg/day may increase the risk of adverse effects. Adverse effects may include dry mouth, headache, dizziness, fatigue, somnolence, tremor, nausea, and diarrhea.
Use:Optimize drug therapy and monitor patient adherence.

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