Sertraline and Desmethylsertraline


Abbrev Code:SERT   
Order Code:LAB1201Order Name:Sertraline
Synonyms:Zoloft
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80332 x1, 80332 x
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; testing is performed Wed, and results are reported within 1-8 days.
Compliance:

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Alternate Containers: Purple (EDTA)
Collection Instructions:Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Causes for Rejection:Gel tubes


Processing and Shipping

Specimen Processing:Centrifuge and separate serum or plasma from cells within 2 hours of collection. Aliquot 1 mL, 0.5 mL minimum, serum or plasma. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 5 days at room temperature; 2 weeks refrigerated; 6 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:98745


Interpretive

Critical Range:Toxic: >300 ng/mL
Reference Range:Not well established.
Sertraline doses ranging from 50-200 mg/d produce serum concentrations ranging from 30-200 ng/mL. Dosing above 200 mg/d is associated with increased adverse effects and decreased efficacy. Adverse effects may include dry mouth, headache, dizziness, somnolence, nausea and diarrhea.
Use:Optimize drug therapy and monitor patient adherence.


Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
systemlabguide@fairview.org for TestID: 2950"