Leukocyte Adhesion Deficiency Panel

Abbrev Code:ARMISC   
Order Code:LAB4909Order Name:Send Outs Misc Test
Synonyms:CD11a; CD11b; CD15s; CD18; FLOLAD; LAD; Beta 2 Integrins
Methodology:Flow cytometry
CPT Codes: 86356 x4
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 1-3 days.
Special Instructions:Sample must be assayed within 48 hours of collection. Results of a CBC and differential, including an eosinophil and basophil count, must be sent with the whole blood specimen.

Collection Instructions

Optimal Volume:5 mL
Minimum\Peds Volume:1 mL
Container:Green (sodium heparin, no gel)
Alternate Containers: Purple (EDTA)
Causes for Rejection:Clotted, hemolyzed or frozen specimens. Specimen received >48 hours after collection.

Processing and Shipping

Specimen Processing:Do not process.
Shipping Instructions:Ship overnight at refrigerated temperature. Specimen must be analyzed within 48 hours of collection.
Stability:48 hours at room temperature or refrigerated.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2004359


Reference Range:
Granulocytes % Positive
CD11a 97-100
CD11b 96-100
CD15s 95-100
CD18 99-100
Use:The Leukocyte Adhesion Deficiency Panel measures the receptors of CD11a, CD11b, CD15 and CD18 normally found on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Decreased values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD11 and CD18 are decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.

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