Immune Complex Panel


Abbrev Code:ICP   
Order Code:LAB3558Order Name:Immune Complex Panel
Synonyms:C1Q Binding Assay; Raji Cell Immune Complex Assay
Methodology:Semi-quantitative enzyme linked immunosorbent assay; Quantitative flow cytometry
CPT Codes: 86332 x2, 86332 x2
Test Includes:C1Q binding and Raji cell immune complex assays.
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 2-9 days.
Compliance:

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.


Collection Instructions

Specimen:Blood
Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Red (no gel)
Alternate Containers: Red or gold (gel)
Causes for Rejection:Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles.


Processing and Shipping

Specimen Processing:Allow sample to clot (up to 1 hour) then separate within 30 minutes. Transfer serum into two 1 mL aliquots, 0.5 mL minimum per aliquot. Keep samples together and freeze immediately. Separate specimens must be sent when multiple tests are ordered.
Shipping Instructions:Ship on dry ice.
Stability:Raji: Room temperature and refrigerated are unacceptable; 30 days frozen
C1q: After separation from cells: 2 hours at room temperature; unacceptable refrigerated; 2 weeks frozen (avoid repeated freeze/thaw cycles)
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3004430


Interpretive

Reference Range:
C1Q Binding Assay Less than or equal to 3.9 μg Eq/mL is considered negative for circulating complement binding immune complexes. Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate the immune complex in a disease process.
Raji Cell Immune Complex Assay By report
Immune complexes bind to Raji Cells via their complement receptors. The immunoglobulin portion of the immune complex is then detected by flow cytometry with anti-human IgG-FITC.
Use:Many autoimmune disorders, chronic infections and malignancies are associated with circulating immune complexes. Quantitation of immune complexes assists in staging immunologic disorders.


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