PSA Total and Free

Abbrev Code:FPSA   
Order Code:LAB171Order Name:PSA Total and Free
Synonyms:Prostatic Specific Antigen; PSA Free; PSA Tumor Marker; PSA Percent Free
Methodology:Electrochemiluminescence immunoassay (ECLIA)
CPT Codes: 84153 x1, 84153 x1, 84154 x1, 84154 x1
Turnaround Time:Testing is performed daily.

Collection Instructions

Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Container:Green (lithium heparin, gel)
Alternate Containers: Green (lithium heparin, no gel), Green (lithium heparin) on ICE, Red (no gel), Red or gold (gel)
Causes for Rejection:Grossly hemolyzed samples.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 4 hours of collection, 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature; alternatively ship on dry ice.
Stability:7 days refrigerated; up to 4 months frozen at -80°C.
Test Performed at or Referral Lab Chemistry  (Roche-UMMC East)


Reference Range:By report. Results include PSA-Free, PSA, PSA-Percent Free.

Roche Free PSA method in conjunction with the Roche tumor marker method to determine the free PSA percentage. The free PSA percentage is an aid in distinguishing prostate cancer from benign prostatic conditions in men age 50 and older with a total PSA between 3 and 10 ng/mL and negative digital rectal examination findings. Prostatic biopsy is required for the diagnosis of cancer.

When Total PSA concentration is in the range of 4.0-10.0 ng/mL, the probability of finding prostate cancer on needle biopsy is:
Probability of Cancer
% PSA Free 50-59 y 60-69 y 70 y & Older
≤10% 49% 58% 65%
11-18% 27% 34% 41%
19-25% 18% 24% 30%
>25% 9% 12% 16%

Other factors may help determine the actual risk of prostate cancer in individual patients.


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