RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG

Sunquest Code:RNPIGG  
Epic Code:LAB6336Epic Name:RNP Antibody IgG
Synonyms:ENA (RNP) Antibody; Extractable Nuclear Antigen Antibody; Ribonucleic Protein (ENA) Antibody; Anti-RNP (ENA) Antibody
Methodology:Fluorescent enzyme immunoassay
Test Includes:RNPA and RNP68
Turnaround Time:Performed Mon-Fri; results reported the same day.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:0.9 mL
Container:Red or gold (gel) (Green (lithium heparin, gel), Purple (EDTA), Red (no gel))
Causes for Rejection:Severely lipemic or hemolyzed specimens.

Processing and Shipping

Specimen Processing:Centrifuge ASAP and aliquot 1 mL, 0.35 mL minimum. Store in refrigerator up to 14 days.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Endocrine  (UMMC-East Bank)


Reference Range:
Negative Less than 5.0 U/mL
Positive Greater than 10 U/mL
Use:RNP antibody is seen in 95-100% of mixed connective tissue disease and is considered specific for this syndrome if other antibodies are negative; RNP is also present in 20-30% of SLE and 15-25% of progressive system sclerosis. RNP antigens also contain epitopes which are immunologically identical to free Smith antigens. The Smith antibody response must be considered when interpreting RNP results.

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