RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG
| Sunquest Code: | RNPIGG | ||
| Epic Code: | LAB6336 | Epic Name: | RNP ANTIBODY IGG |
| Synonyms: | ENA (RNP) Antibody; Extractable Nuclear Antigen Antibody; Ribonucleic Protein (ENA) Antibody; Anti-RNP (ENA) Antibody | ||
| Methodology: | Multiplex flow immunoassay | ||
| Test Includes: | RNPA and RNP68 | ||
| Turnaround Time: | Performed Mon-Fri; results reported the same day. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 0.9 mL |
| Container: | Red or gold (gel) (Green (lithium heparin, gel), Green (sodium heparin, no gel), Purple (EDTA), Red (no gel)) |
| Causes for Rejection: | Severely lipemic or hemolyzed specimens. |
Processing and Shipping
| Specimen Processing: | Centrifuge ASAP and aliquot 1 mL, 0.35 mL minimum. Store in refrigerator up to 7 days. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Test Performed at or Referral Lab | Specialty Core (UMMC-East Bank) |
Interpretive
| Reference Range: |
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| Use: | RNP antibody is seen in 95-100% of mixed connective tissue disease and is considered specific for this syndrome if other antibodies are negative; RNP is also present in 20-30% of SLE and 15-25% of progressive system sclerosis. RNP antigens also contain epitopes which are immunologically identical to free Smith antigens. The Smith antibody response must be considered when interpreting RNP results. |
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