Sirolimus


Abbrev Code:RAPA   
Order Code:LAB875Order Name:Sirolimus Level
Order Instructions:Comment last dose information. Do not cancel this test if the specimen is frozen, comment "Specimen frozen" when test requesting.
Synonyms:Rapamune; Rapamycin
Methodology:Liquid chromatography/tandem mass spectrometry
CPT Codes: 80195 x1
Turnaround Time:Performed and reported daily if received in Drug Analysis by 9:30 am. For levels outside of this time frame, contact Drug Analysis at 612-273-5838.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.4 mL
Container:Purple (EDTA)
Collection Instructions:Usual sampling time is immediately prior to next dose, but no sooner than 2 hours before.
Causes for Rejection:Clotted specimen.


Processing and Shipping

Specimen Processing:Do not process whole blood. Store at room temperature or refrigerated.
Shipping Instructions:Ship at room temperature.
UMMC-West Bank only: Send STAT.
Stability:Up to 28 days at room temperature (19-26ºC) or refrigerated (2-8ºC). For longer storage, freeze at -10ºC or colder.
Test Performed at or Referral Lab Drug Analysis  (UMMC-East Bank)


Interpretive

Critical Range:Greater than 20 ug/L
Therapeutic Range:
Kidney Transplant ug/L
          6-12 mo 8-10
          Greater than 12 mo 5-8
          Greater than 5 y 4-6
Heart Transplant 4-10
Lung Transplant 5-15
Hematopoietic Stem Cell 3-12
Pediatric BMT 3-12
   
Use:Therapeutic drug monitoring and to assess toxicity.


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