Venlafaxine (Effexor) and Desmethylvenlafaxine (Metabolite) Serum/Plasma


Abbrev Code:VENDES   
Order Code:LAB1238Order Name:Venlafaxine
Synonyms:Effexor
Methodology:Quantitative liquid chromatography/Tandem mass spectrometry
CPT Codes: 80338 x1, 80338 x1
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; testing is performed Wed and Sat.  Results are reported within 1-5 days.
Compliance:

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Alternate Containers: Purple (EDTA)
Collection Instructions:Predose (trough) draw - At steady state concentration.
Causes for Rejection:Whole blood. Collected in gel, light blue (citrate), or yellow (SPS or ACD solution) tubes.


Processing and Shipping

Specimen Processing:Centrifuge and separate serum/plasma from cells within 2 hours of collection. Aliquot 1 mL, 0.5 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:2 weeks at room temperature, refrigerated or frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2007957


Interpretive

Critical Range:Toxic level: ≥800 ng/mL.
Adverse effects to venlafaxine therapy may include nausea, vomiting, dizziness, tremors and blurred vision.
Therapeutic Range:195-400 ng/mL
The therapeutic range is based on serum predose (trough) draw at steady state concentration.
Use:Optimize drug therapy and monitor patient adherence.


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