Encainide, ODE and MODE

Abbrev Code:XMISC   
Order Code:LAB4909Order Name:Laboratory Miscellaneous Order
Methodology:Liquid chromatography/Tandem mass spectrometry
CPT Codes: x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Fri; results are reported within 4 days.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:0.6 mL
Container:Red (no gel)
Alternate Containers: Green (lithium heparin, no gel), Green (sodium heparin, no gel)
Collection Instructions:Trough level preferred.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.24 mL minimum. Store at room temperature.
Shipping Instructions:Ship at room temperature.
Test Performed at or Referral Lab Lab Sendouts  (MedTox)
Referral Lab number:176


Critical Range:


Critical Value


Greater than 2500 ng/mL

o-Demethylencainide (ODE)

Greater than 1200 ng/mL

3-Methoxy-ODE (MODE)

Greater than 1500 ng/mL



Reference Range:


Reference Range


15-100 ng/mL

o-Demethylencainide (ODE)

100-300 ng/mL

3-Methoxy-ODE (MODE)

60-300 ng/mL

10% of patients do not form therapeutic concentrations of active metabolites, ODE and MODE. In these patients the recommended range for the encainide concentration is 300-1200 ng/mL.


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