Risperidone and 9-Hydroxyrisperidone


Abbrev Code:RIS   
Order Code:LAB1204Order Name:Risperdal Quantitative
Order Instructions:This test detects risperidone (parent) AND paliperidone (9-hydroxyrisperidone and metabolite). For paliperidone (9-hydroxyrisperidone) only, order Paliperidone.
Synonyms:Risperdal
Methodology:Quantitative Liquid chromatography/Tandem mass spectrometry
CPT Codes: 80342 x1, 80342 x1
Test Includes:9-Hydroxyrisperidone
Turnaround Time:Specimens are sent to the reference laboratory Sun-Sat; testing is performed Mon, Wed, and Fri. Results are reported within 1-5 days.
Compliance:

ARUP Laboratory Developed Test (LDT): For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red (no gel)
Alternate Containers: Purple (EDTA)
Collection Instructions:Pre-dose (trough) draw - At steady state concentration.


Processing and Shipping

Specimen Processing:Centrifuge and separate from cells ASAP or within 2 hours of collection. Aliquot 1 mL, 0.5 mL minimum, serum or plasma. Store in refigerator. 
Shipping Instructions:Ship at refrigerated temperature.
Stability:2 weeks at room temperature or refrigerated; 2 months frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2007951


Interpretive

Critical Range:Toxic level: >120 ng/mL
Therapeutic Range:Risperidone: 20-60 ng/mL
Paliperidone (9-hydroxyrisperidone): 20-60 ng/mL
Use:Optimize drug therapy and monitor patient adherence.


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