Estradiol, Ultrasensitive


Abbrev Code:E2S   
Order Code:LAB3440Order Name:Estradiol Ultrasensitive
Synonyms:E2, Ultrasensitive
Methodology:Liquid chromatography/Tandem mass spectrometry
CPT Codes: 82670 x1
Turnaround Time:Performed once/week; results are reported within 7 days.
Special Instructions:Specimens on pre-pubertal children, males and post-menopausal women should be performed using this ultrasensitive method. Adult females of child-bearing age should be performed using chemiluminescence method.


Collection Instructions

Specimen:Blood
Optimal Volume:3 mL
Minimum\Peds Volume:1.3 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Samples not separated from cells within 2 hours of collection.


Processing and Shipping

Specimen Processing:Within 2 hours centrifuge and aliquot 1 mL, 0.5 mL minimum. Store frozen.
Shipping Instructions:Ship on dry ice.
Stability:After separation from cells: 7 days refrigerated. For longer storage freeze.
Test Performed at or Referral Lab UM Special Drug/Biochemical Genetics (Y)  (UMMC East Bank)


Interpretive

Reference Range:

 

Prepubertal females

0-20 pg/mL

Premenopausal females

15-350 pg/mL**

Post-menopausal females

0-10 pg/mL

Prepubertal males

0-13 pg/mL

Adult males

10-40 pg/mL

Children

1-14 days: Estradiol levels in newborns are very elevated at birth, but will fall to prepubertal levels within a few days.

**Estradiol levels may vary widely through the menstrual cycle.

 

Females

Tanner Stages

Mean Age

Reference Range

Stage 1 (>14 d and prepubertal)

7.1 y

Undetectable-20 pg/mL

Stage II

10.5 y

Undetectable-24 pg/mL

Stage III

11.6 y

Undetectable-60 pg/mL

Stage IV

12.3 y

15-85 pg/mL

Stage V

14.5 y

15-350 pg/mL **

Puberty onset (transition from Tanner Stage I to Tanner Stage II) occurs for girls at a median age of 10.5 y (±2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner Stage V (adult) should be reached by age 18.

 

Males

Tanner Stages

Mean Age

Reference Range

Stage 1 (>14 d and prepubertal)

7.1 y

Undetectable-13 pg/mL

Stage II

12.1 y

Undetectable-16 pg/mL

Stage III

13.6 y

Undetectable-26 pg/mL

Stage IV

15.1 y

Undetectable-38 pg/mL

Stage V

18 y

10-40 pg/mL **

Puberty onset (transition from Tanner Stage I to Tanner Stage II) occurs for boys at a median age of 11.5 y (±2) years. For boys, there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner Stage V (adult) should be reached by age 18.

 

Use:For evaluation of feminization in men.


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