Valproic Acid, Free and Total
| Abbrev Code: | VALPFR | ||
| Order Code: | LAB5847 | Order Name: | Valproic Acid Free and Total |
| Synonyms: | Free Depakene; Free Depakote | ||
| Methodology: | Quantitative enzyme multiplied immunoassay technique | ||
| CPT Codes: | 80165 x1, 80165 x1, 80164 x1, 80164 x1 | ||
| Turnaround Time: | Routine specimens are sent to reference laboratory Sun-Sat; results are reported within 1-3 days. | ||
| Compliance: | This test uses an in vitro diagnostic (IVD) that has been cleared or approved by the FDA. |
||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 4 mL |
| Minimum\Peds Volume: | 2.2 mL |
| Container: | Red (no gel) |
| Collection Instructions: | Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. |
| Causes for Rejection: | Specimens collected in light blue (citrate), gray (oxalate), green (heparin), K2EDTA plasma; tubes that contain liquid anticoagulant, or gel separator tubes. |
Processing and Shipping
| Specimen Processing: | Separate serum from cells within 2 hours of collection and aliquot 2 mL, 1 mL minimium, serum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | Roche: 2 days at room temperature; 1 week refrigerated; 3 months frozen. Do not freeze-thaw more than 5 times.
Vista: 24 hours at room temperature; 1 week refrigerated; 1 month frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 0099310 |
Interpretive
| Critical Range: |
|
||||
| Reference Range: | Valproic Acid Percent Free: 5-18% | ||||
| Therapeutic Range: |
|
||||
| Use: | Preferred test for therapeutic drug management in patients with renal failure or conditions that may alter albumin concentrations.
Free valproic acid may be important to monitor patients with altered or unpredictable protein binding capacity because valproic acid exhibits variable, dose-dependent protein binding, Valproic acid is also subject to drug-drug interactions due to displacement of protein binding. Calculating percent free attempts to minimize differences in test cross-reactivity and may be useful in dose optimization. Adverse effects may include headache, somnolence and dizziness. |
Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
[email protected] for TestID: 3507"