Histone Antibody, IgG

Abbrev Code:HSTON   
Order Code:LAB3548Order Name:Histone Antibody IgG
Synonyms:Anti-histone Antibody IgG; Drug Induced SLE
Methodology:Enzyme-linked immunosorbent assay
CPT Codes: 83516 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-4 days.

Collection Instructions

Optimal Volume:1 mL
Minimum\Peds Volume:0.8 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Grossly hemolyzed, icteric or lipemic specimens. Plasma or urine.

Processing and Shipping

Specimen Processing:Separate serum from cells ASAP. Centrifuge and aliquot 0.5 mL, 0.3 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50860 (AHA)


Reference Range:

None detected

Less than 1.0 Units


1.0-1.5 Units


1.6-2.5 Units

Strong positive

Greater than 2.5 Units



Use:Histone antibodies are present in 20-55% of idiopathic SLE and 80-95% of drug induced SLE. They occur in less than 20% of other types of connective tissue diseases.

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