Methylmalonic Acid
| Abbrev Code: | MMALA | ||
| Order Code: | LAB8135 | Order Name: | Methylmalonic Acid |
| Synonyms: | MMA; Methylmalonate | ||
| Methodology: | Liquid chromatography/Tandem mass spectrometry | ||
| CPT Codes: | 83921 x1 | ||
| Turnaround Time: | Performed once per week; results are reported the next day. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 1.2 mL |
| Minimum\Peds Volume: | 0.8 mL |
| Container: | Red or gold (gel) Alternate Containers: Green (sodium heparin, no gel), Purple (EDTA), Red (no gel) |
| Causes for Rejection: | Grossly hemolyzed or lipemic specimens. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot within 2 hours of collection 0.5 mL, 0.3 mL minimum. |
| Shipping Instructions: | Ship on dry ice. |
| Stability: | 4 days refrigerated; 30 days frozen. |
| Test Performed at or Referral Lab | UM Special Drug/Biochemical Genetics (Y) (UMMC East Bank) |
Interpretive
| Reference Range: | 0.00 - 0.40 umol/L |
| Use: | Diagnose and monitor methylmalonic aciduria caused by Vitamin B12 deficiency, Methylmalonyl CoA mutase enzyme defect, Cob(I)alamine synthesis (cb1A, cb1B, cb1C, cb1D or cb1F) pathway defects, Propionic acidemia, Homocystinuria or Pernicious anemia. |
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