Liver-Kidney Microsome Antibody, IgG

Abbrev Code:LKAB   
Order Code:LAB3588Order Name:Liver Kidney Microsomal Antibody IGG
Methodology:Indirect fluorescent antibody
CPT Codes: 86376 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days.

For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:0.5 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Severely hemolyzed, severely lipemic

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.15 mL minimum.
Shipping Instructions:Ship on dry ice.
Stability:2 weeks refrigerated.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:99270 (LIVER-KID)


Reference Range:Less than 1:20 Normal
Use:Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Use in combination with Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG when evaluating for AIH-2.  Liver-Kidney Microsome IgG antibody (anti-LKM), as detected by indirect immunofluorescent antibody (IFA) techniques, may be observed in patients with autoimmune hepatitis type 2 (AIH-2), AIH-2 associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), viral hepatitis C or D, and some forms of drug-induced hepatitis. This IFA does not differentiate among the four types of LKM antibodies (LKM-1, LKM-2, LKM-3, and a fourth type that recognizes CYP1A2 and CYP2A6 antigens). Of these, anti-LKM-1 (cytochrome P450IID6) IgG antibodies are considered specific for AIH-2.

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