Liver-Kidney Microsome Antibody, IgG
| Abbrev Code: | LKAB | ||
| Order Code: | LAB3588 | Order Name: | Liver Kidney Microsomal Antibody IGG |
| Methodology: | Indirect fluorescent antibody | ||
| CPT Codes: | 86376 x1 | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported in 1-5 days. | ||
| Compliance: | For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 0.5 mL |
| Container: | Red or gold (gel) Alternate Containers: Red (no gel) |
| Causes for Rejection: | Severely hemolyzed, severely lipemic |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 1 mL, 0.15 mL minimum. |
| Shipping Instructions: | Ship on dry ice. |
| Stability: | 2 weeks refrigerated. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 99270 (LIVER-KID) |
Interpretive
| Reference Range: | Less than 1:20 Normal |
| Use: | Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Use in combination with Liver Cytosolic Antigen Type 1 (LC-1) Antibody, IgG when evaluating for AIH-2. Liver-Kidney Microsome IgG antibody (anti-LKM), as detected by indirect immunofluorescent antibody (IFA) techniques, may be observed in patients with autoimmune hepatitis type 2 (AIH-2), AIH-2 associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), viral hepatitis C or D, and some forms of drug-induced hepatitis. This IFA does not differentiate among the four types of LKM antibodies (LKM-1, LKM-2, LKM-3, and a fourth type that recognizes CYP1A2 and CYP2A6 antigens). Of these, anti-LKM-1 (cytochrome P450IID6) IgG antibodies are considered specific for AIH-2. |
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