Thiopurine Metabolites by LC-MS/MS
| Sunquest Code: | THIOMT | ||
| Epic Code: | LAB7078 | Epic Name: | Thiopurine Metabolites by LC-MS/MS |
| Synonyms: | 6 Thioguanine; 6 Methylmercaptopurine; Thiopurine Level | ||
| Methodology: | Liquid chromatography/Tandem mass spectrometry | ||
| Test Includes: | 6-TGN and 6-MMPN levels | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Mon-Sat; results are reported within 3-5 days. | ||
Collection Instructions
| Specimen: | Whole Blood |
| Optimal Volume: | 3 mL |
| Minimum\Peds Volume: | 1.5 mL |
| Container: | Purple (EDTA) |
| Patient Preparation: | Trough collection (within 1 hour prior to the next dose). |
| Causes for Rejection: | Frozen or hemolyzed. Icteric or lipemic samples |
Processing and Shipping
| Specimen Processing: | Do not process or aliquot. Whole blood. Store in refrigerator. Do not freeze. |
| Shipping Instructions: | Ship at refrigerated temperature in original container. |
| Stability: | 24 hours at room temperature; 8 days refrigerated. |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo) |
| Referral Lab number: | THIO |
Interpretive
| Reference Range: |
6-Thioguanine Nucleotides (6-TGN): 235-450 pmol/8x10(8) RBC.
6-Methylmercaptopurine (6-MMP): Less than or equal to 5700 pmol/8x10(8) RBC. |
| Use: |
Optimize therapy for thiopurine drugs. Identify thiopurine metabolite concentrations that may lead to toxicity.
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