Thiopurine Metabolites by LC-MS/MS


Sunquest Code:THIOMT  
Epic Code:LAB7078Epic Name:Thiopurine Metabolites by LC-MS/MS
Synonyms:6 Thioguanine; 6 Methylmercaptopurine; Thiopurine Level
Methodology:Liquid chromatography/Tandem mass spectrometry
Test Includes:6-TGN and 6-MMPN levels
Turnaround Time:Specimens are sent to the reference laboratory Mon-Sat; results are reported within 3-5 days.


Collection Instructions

Specimen:Whole Blood
Optimal Volume:3 mL
Minimum\Peds Volume:1.5 mL
Container:Purple (EDTA)
Patient Preparation:Trough collection (within 1 hour prior to the next dose).
Causes for Rejection:Frozen or hemolyzed.  Icteric or lipemic samples


Processing and Shipping

Specimen Processing:Do not process or aliquot. Whole blood. Store in refrigerator. Do not freeze.
Shipping Instructions:Ship at refrigerated temperature in original container.
Stability:24 hours at room temperature; 8 days refrigerated.
Test Performed at or Referral Lab Lab Sendouts  (Mayo)
Referral Lab number:THIO


Interpretive

Reference Range:
6-Thioguanine Nucleotides (6-TGN): 235-450 pmol/8x10(8) RBC.
6-Methylmercaptopurine (6-MMP):  Less than or equal to 5700 pmol/8x10(8) RBC.
     
Use:
Optimize therapy for thiopurine drugs. Identify thiopurine metabolite concentrations that may lead to toxicity.  


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