Thiopurine Metabolites by LC-MS/MS
Abbrev Code: | THIOMT | ||
Order Code: | LAB7078 | Order Name: | Thiopurine Metabolites by LC-MS/MS |
Synonyms: | 6 Thioguanine; 6 Methylmercaptopurine; Thiopurine Level | ||
Methodology: | Liquid chromatography/Tandem mass spectrometry | ||
CPT Codes: | 80299 x1 | ||
Test Includes: | 6-TGN and 6-MMPN levels | ||
Turnaround Time: | Specimens are sent to the reference laboratory Mon-Sat; results are reported within 3-5 days. |
Collection Instructions
Specimen: | Whole Blood |
Optimal Volume: | 3 mL |
Minimum\Peds Volume: | 1.5 mL |
Container: | Purple (EDTA) |
Patient Preparation: | Trough collection (within 1 hour prior to the next dose). |
Causes for Rejection: | Frozen or hemolyzed. Icteric or lipemic samples |
Processing and Shipping
Specimen Processing: | Do not process or aliquot. Whole blood. Store in refrigerator. Do not freeze. |
Shipping Instructions: | Ship at refrigerated temperature in original container. |
Stability: | 24 hours at room temperature; 8 days refrigerated. |
Test Performed at or Referral Lab | Lab Sendouts (Mayo) |
Referral Lab number: | THIO |
Interpretive
Reference Range: |
6-Thioguanine Nucleotides (6-TGN): 235-450 pmol/8x10(8) RBC.
6-Methylmercaptopurine (6-MMP): Less than or equal to 5700 pmol/8x10(8) RBC. |
Use: |
Optimize therapy for thiopurine drugs. Identify thiopurine metabolite concentrations that may lead to toxicity.
|
Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
systemlabguide@fairview.org for TestID: 3804"