Metanephrines, Plasma, Free

Abbrev Code:METPLF   
Order Code:LAB6760Order Name:Metanephrines, Plasma Free
Synonyms:Metanephrines and Normethnephine, Free
Methodology:Liquid chromatography/tandem mass spectrometry
CPT Codes: 83835 x1
Test Includes:Metanephrine and Normetanephrine
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-4 days.

For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Collection Instructions

Optimal Volume:4 mL
Minimum\Peds Volume:2.2 mL
Container:Purple (EDTA)
Alternate Containers: Green (sodium heparin, no gel)
Patient Preparation:Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection if possible. Collection of the specimen after the patient has rested for 15 minutes in a supine position is recommended.
Causes for Rejection:Plasma separator tubes. Body fluids other than EDTA or heparinized plasma. Non-frozen and grossly hemolyzed specimens.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot within 1 hour of collection. Freeze immediately. 2 mL, 1 mL minimum. Store frozen. Separate specimens must be submitted when multiple tests are ordered.
Shipping Instructions:Ship on dry ice.
Stability:After separation from cells: 1 month frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:50184


Reference Range:Metanephrine: 0.0-0.89 nmol/L; Normetanephrine: 0.0-0.49 nmol/L
Use:This test is useful in the detection of pheochromocytoma, a rare neuroendocrine tumor. The majority of patients with pheochromocytoma have a plasma normetanephrine concentration in excess of 2.2 nmol/L and/or a metanephrine concentration in excess of 1.1 nmol/L. Increased concentrations of these analytes serve as confirmation for diagnosis. Patients with essential hypertension and plasma concentrations of normetanephrine below 0.9 nmol/L and a metanephrine concentration below 0.5 nmol/L can be excluded from further testing. If clinical suspicion remains, repeat testing or testing for metanephrines in a 24-hour urine specimen should be considered.

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