Maternal Serum Screen, Alpha Fetoprotein, hCG, Estriol and Inhibin A (Quad)

Abbrev Code:MQMK   
Order Code:LAB3619Order Name:Maternal Quad Marker 2nd Trimester
Synonyms:Maternal Quad Marker; AFP; MQMK; Alpha Fetoprotein; hCG; Estriol and Inhibin
Methodology:Quantitative chemiluminescent immunoassay
CPT Codes: 81511 x1
Turnaround Time:Specimens are sent to reference laboratory Mon-Sun; results are reported in 2-3 days.
Special Instructions:
Second trimester screening test for trisomy 21 (Down syndrome), trisomy 18 and open neural tube defects.
  1. Patient's date of birth
  2. Current weight
  3. Due date
  4. Method used for determining the due date (US, LMP)
  5. If this is a repeat sample
  6. Number of fetuses present (if known)
  7. Patient's race
  8. If the patient was diabetic at the time of conception
  9. If there is a known family history of neural tube defects
  10. Physician's name and phone number
  11. Indicate if the patient is taking valproic acid or carbamazepine
  12. If the patient is currently smoking
  13. Did patient have previous pregnancy wtith trisomy
  14. Age of egg donor if in vitro fertilization
Associated Links:

ARUP Maternal Serum Testing Patient Form

Collection Instructions

Optimal Volume:6 mL
Minimum\Peds Volume:2.2 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Collection Instructions:Send to the laboratory immediately after collection.
Patient Preparation:Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for maternal serum screening is 16 to 18 weeks gestation.
Causes for Rejection:Plasma; hemolysis

Processing and Shipping

Specimen Processing:Centrifuge within 2 hours of collection; aliquot 3 mL, 1 mL minimum. Store refrigerated.
Shipping Instructions:Ship at refrigerated temperature.
Stability:72 hours at room temperature; 2 weeks refrigerated; 1  year frozen. Avoid repeated freeze/thaw cycles.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3000143


Reference Range:By report.
Use:This test is used to screen for fetal risk of Down syndrome (trisomy 21), trisomy 18, and Open Neural Tube Defect (ONTD, spina bifida).

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