Myelin Associated Glycoprotein (MAG) Autoantibody


Abbrev Code:MAGAB   
Order Code:LAB7016Order Name:MAG and SGPG Antibodies, IgM
Synonyms:MAG Dual Antigen Autoantibody; Myelin Associated Glycoprotein (MAG) and Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies IgM
Methodology:Enzyme-linked immunosorbent assay
CPT Codes: 83516 x2
Turnaround Time:Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-10 days.
Compliance:

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.



Collection Instructions

Specimen:Blood
Optimal Volume:1 mL
Minimum\Peds Volume:0.4 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Causes for Rejection:Urine, contaminated, heat-inactivated, hemolyzed, icteric or severely lipemic specimens,


Processing and Shipping

Specimen Processing:Within 2 hours of collection, centrifuge and aliquot 0.5 mL, 0.1 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells, specimens are stable for 48 hours at room temperature, 2 weeks refrigerated and 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:2004412


Interpretive

Reference Range:

 

Myelin Associated Glucoprotein (MAG) Antibody, IgM: Less than 1000 TU

Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM: Less than 1.00 IV

 

Use:An elevated IgM antibody concentration greater than 999 TU against myelin-associated glycoprotein (MAG) suggests active demyelination in peripheral neuropathy. A normal concentration (less than 999 TU) generally rules out an anti-MAG antibody-associated peripheral neuropathy. The majority of sulfate-3-glucoronyl paragloboside (SGPG) IgM positive sera will s how reactivity against MAG. Patients who are SGPG IgM positive and MAG IgM negative may have multi-focal motor neuropathy with conduction block. TU = Titer Units.


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