Alpha Fetoprotein, Maternal Serum Screen

Abbrev Code:AFPM   
Order Code:LAB692Order Name:Alpha Fetoprotein Maternal Screen
Synonyms:Maternal Serum Screen, Alpha Fetoprotein; AFP
Methodology:Chemiluminescent immunoassay
CPT Codes: 82105 x1
Turnaround Time:Specimens are sent to the reference laboratory Mon-Sat; results are reported within 2-3 days.
Special Instructions:
The patient must be between 14-25 weeks gestation. The following information is required and must accompany the sample in order for testing to be interpreted:
  1. Patient's date of birth
  2. Current weight
  3. Due date
  4. Method used for determining the due date (US, LMP)
  5. If this is a repeat sample
  6. Number of fetuses present (if known)
  7. Patient's race
  8. If the patient was diabetic at the time of conception
  9. If there is a known family history of neural tube defects
  10. Physician's name and phone number
  11. Indicate if the patient is taking valproic acid or carbamazepine
  12. If the patient is currently smoking


Associated Links:

ARUP Maternal Serum Testing Patient Form

Collection Instructions

Optimal Volume:2 mL
Minimum\Peds Volume:1.2 mL
Container:Red or gold (gel)
Alternate Containers: Red (no gel)
Collection Instructions:Avoid repeated freeze/thaw cycles.
Causes for Rejection:Hemolyzed specimens. Plasma.

Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1 mL, 0.5 mL minimum, serum within 2 hours of collection. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:After separation from cells: 72 hours at room temperature; 2 weeks refrigerated; 1 year frozen.
Test Performed at or Referral Lab Lab Sendouts  (ARUP)
Referral Lab number:3000144


Reference Range:By report.
Use:This test is used to screen for fetal risk of open neural tube defect (i.e. spina bifida).

Click HERE to Report test errors or omissions.
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