Tissue Transglutaminase Antibodies, IgA and IgG

Abbrev Code:TTGABY   
Order Code:LAB3796Order Name:Tissue Transglutaminase ABY IGA and IGG
Synonyms:TTG Antibodies; Celiac Disease; Sprue; Gluten Sensitivity; Reticulin Antibody
Methodology:FEIA (by ImmunoCAP)
CPT Codes: 86364 x2, 86364 x2
Turnaround Time:Performed Mon-Fri; results are reported the same day.

Collection Instructions

Optimal Volume:1 mL
Minimum\Peds Volume:0.6 mL
Container:Red or gold (gel)
Alternate Containers: Purple (EDTA), Red (no gel)
Causes for Rejection:Hemolyzed, lipemic or microbially contaminated specimens. Samples not separated from cells within 2 hours of collection.

Processing and Shipping

Specimen Processing:Within 2 hours of collection, centrifuge and aliquot 0.5 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:2 weeks refrigerated.
Test Performed at or Referral Lab UM Specialty Core/Prot/Endo (Phadia ELiA G) 


Reference Range:
Tissue Transglutaminase Antibody, IgA
Less than 7.0 U/mL Negative
7.0-10.0 U/mL Equivocal
Greater than 10.0 U/mL Positive
  Tissue Transglutaminase Antibody, IgG
Less than 7.0 U/mL Negative
7.0-10.0 U/mL Equivocal
Greater than 10.0 U/mL Positive
Use:Celiac disease is an autoimmune digestive disease characterized by a permanent intolerance to gluten. Gluten triggers an inflammatory immune response in the mucosa of the small intestine. A gluten-free diet can completely stop the immune response and the small intestine can repair itself. The antibody levels decline and eventually disappear. Reintroduction of gluten retriggers the response. Serological screening offers a minimally invasive option for rapid identification of patients likely to have celiac disease and to select those who should be subjected to biopsy. Various autoantibodies are produced by patients. TTG (tissue transglutaminase) is the primary autoantigen recognized by endomysial antibodies in patients with celiac disease and may be the most useful first-level screening test for celiac disease. IgA antibodies usually predominate, but IgG antibodies may also be produced.

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