Factor 10, Chromogenic


Abbrev Code:F10CH   
Order Code:LAB758Order Name:Factor 10 Chromogenic
Synonyms:Factor 10, Chromogenic; Factor X Chromogenic
Methodology:Chromogenic (synthetic substrate) activity assay
CPT Codes: 85260 x1, 85260 x1
Turnaround Time:Within 8 hours if received into the testing laboratory by 2 p.m. Testing performed 6 days per week. With pre-notification, STATs are done within 1 hour after receipt in the testing laboratory.
Associated Links:

Specimen Collection and Processing for Coagulation Specimens


Collection Instructions

Specimen:Blood
Optimal Volume:2.7 mL (in 3 mL tube) - filled to fill line on the tube.
Minimum\Peds Volume:1.8 mL (in 2 mL tube) - filled to fill line on the tube.
Container:Blue Na Citrate, 3.2% - fill to fill line on tube
Collection Instructions:See link to Specimen Collection and Processing for Coagulation Specimens.
Causes for Rejection:Underfilled tubes, overfilled tubes, clotted specimens, not received or processed and frozen within 4 hours of collection or, specimen thawed during transit.


Processing and Shipping

Specimen Processing:
  • Process for Platelet Poor Plasma within 4 hours of collection.
  • Aliquot plasma, place clear tape around label, and freeze at -20C or on dry ice within 4 hours of collection.
  • If multiple tests are collected on 1 blue top, split each blue top into 2 aliquots. Minimum 0.5 mL per tube.
  • A maximum of 6 aliquots are needed per collection.
     
See link to Specimen Collection and Processing for Coagulation Specimens.
Shipping Instructions:
  • Ensure specimen is frozen before shipping.
  • Ship on dry ice, sample must remain frozen during shipping.
     
See link to Specimen Collection and Processing for Coagulation Specimens.
Test Performed at or Referral Lab UM Special Coag (K)  (UMMC East Bank)


Interpretive

Critical Range:Less than 10%
Reference Range:70-130%
Therapeutic Range:A chromogenic factor 10 level of approximately 20 to 40 percent inversely correlates with an INR of 2 to 3 for patients receiving warfarin. Chromogenic factor 10 levels below 20 percent indicate an INR greater than 3, and levels above 40 percent indicate an INR less than 2.
Use:This test may be used to monitor warfarin therapy for patients with lupus anticoagulants.


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