FISH for Bladder Cancer


Sunquest Code:FISHCTCoPath Code:CYTO-FISH
Epic Code:LAB4715Epic Name:FISH Bladder Cancer
Order Instructions:FISH UroVysion in CoPath
Synonyms:UroVysion for Bladder Cancer
Methodology:Fluorescence in-situ hybridization
Turnaround Time:Performed Mon-Fri; 0800-1500; results are reported within 10 days.
Special Instructions:Request form should include date and time of specimen collection, attending physician, diagnosis, clinical status and specimen type.


Collection Instructions

Specimen:Urine (voided and catheterized)
Optimal Volume:35-100 mL
Minimum\Peds Volume:35 mL
Container:ThinPrep UroCyte urine collection kit (Plastic leakproof container, sterile, Sterile tube)
Collection Instructions:
If both Cytology and FISH for Bladder Cancer are ordered, all specimens should be collected in the Urocyte urine collection kit container.

Do not collect urine after cystoscopy to avoid lubricant contamination. If performing cystoscopy, collect urine prior to procedure with clean catch technique. Obtain second or later morning specimen in sterile urine cup or Thin Prep Urocyte Urine Collection Kit container.
Causes for Rejection:Specimens delivered on weekends or received after 24 h without ethanol or other genetic preservative added.


Processing and Shipping

Specimen Processing:Store in refrigerator.
Shipping Instructions:Ship specimen container at refrigerated temperature to arrive within 2 hrs of collection. Ship specimen container at room temperature if collected in ThinPrep Urocyte urine collection kit.ThinPrep UroCyte Vial is provided by UMMC East Core Sendouts upon request.
Stability:
  • Fresh unfixed fluid: 1 week at refrigerated temperature; frozen is unacceptable.
  • Fixed fluid: 1 week at refrigerated temperature; frozen is unacceptable.
Test Performed at or Referral Lab Cytology  (UMMC-East Bank)


Interpretive

Reference Range:Reported as negative or positive UroVysion test.
Use:Assess urine specimens from persons with hematuria suspected of having bladder cancer and subsequent monitoring for tumor recurrence in patients previously diagnosed with bladder cancer utilizing UroVysion Test for Bladder Cancer. The test is designed for the detection and quantification of chromosomes 3, 7, and 17, and the 9p21 locus in human urine specimens by Florescent in Situ Hybridization. Does not rule out low grade TCC.


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