FISH for Bladder Cancer

Abbrev Code:FISHCT   
Order Code:LAB4715Order Name:FISH Bladder Cancer
Order Instructions:FISH UroVysion in CoPath
Synonyms:UroVysion for Bladder Cancer
Methodology:Fluorescence in-situ hybridization
CPT Codes: 88368-26 x4, 88120 x4
Turnaround Time:Performed Mon-Fri; 0800-1500; results are reported within 10 days.
Special Instructions:Provide pertinent clinical history.

Collection Instructions

Specimen:Urine (voided and catheterized); Bladder Washing
Optimal Volume:35-100 mL
Minimum\Peds Volume:35 mL
Container:ThinPrep UroCyte urine collection kit
Alternate Containers: Plastic leakproof container, sterile
Collection Instructions:If both Cytology and FISH for Bladder Cancer are ordered, all specimens should be collected in the Urocyte urine collection kit container. 
  1. Follow instructions included with Urocyte Urine Collection Kit.
  2. If kit is not used, submit a random urine specimen with an equal volume of 70% ethanol, PreservCyt, or CytoLyt.
Causes for Rejection:Unfixed specimens 48 hours after collection.

Processing and Shipping

Specimen Processing:Store in refrigerator.
Shipping Instructions:Ship unfixed specimen container at refrigerated temperature to arrive within 48 hrs of collection. Ship specimen container at room temperature if collected in PreservCyt or CytoLyt.
  • Fresh unfixed fluid: 48 hrs at refrigerated temperature; frozen is unacceptable.
  • Fixed fluid: 1 week at refrigerated temperature; frozen is unacceptable.
Test Performed at or Referral Lab UM Cytology  (UMMC East Bank)


Reference Range:Reported as negative or positive UroVysion test.
Use:Assess urine specimens from persons with hematuria suspected of having bladder cancer and subsequent monitoring for tumor recurrence in patients previously diagnosed with bladder cancer utilizing UroVysion Test for Bladder Cancer. The test is designed for the detection and quantification of chromosomes 3, 7, and 17, and the 9p21 locus in human urine specimens by Florescent in Situ Hybridization. Does not rule out low grade TCC.

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