Thiopurine Methyltransferase (TPMT), RBC
| Abbrev Code: | TPMT | ||
| Order Code: | LAB6987 | Order Name: | Thiopurine Methyltransferase, RBC |
| Synonyms: | Thiopurine Methyltransferase (TPMT) Enzyme Activity Level; 6-Mercaptopurine | ||
| Methodology: | Enzymatic/Liquid chromatography/Tandem mass spectrometry | ||
| CPT Codes: | 84433 x1, 84433 x1 | ||
| Turnaround Time: | Specimens are sent to the reference laboratory Mon-Sat; results are reported within 3-5 days. | ||
| Compliance: | For tests developed and validated by ARUP (previously referred to as Compliance Statement B, C or D). This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Whole Blood |
| Optimal Volume: | 5 mL |
| Minimum\Peds Volume: | 3 mL |
| Container: | Purple (EDTA) Alternate Containers: Green (sodium heparin, no gel) |
| Collection Instructions: | Refrigerate within 3 hours of collection. |
| Causes for Rejection: | Gel separator tube. Specimens collected in sodium fluoride/potassium oxalate (gray) tube. Hemolyzed, frozen or room temperature specimens. |
Processing and Shipping
| Specimen Processing: | Do not process. Whole blood. Store in refrigerator. Do not freeze. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | 3 hours at room temperature; 6 days refrigerated. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 92066 |
Interpretive
| Reference Range: |
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| Use: | Phenotype test to assess risk for severe myelosuppression with standard dosing of thiopurine drugs. Can also detect rapid metabolizer phenotype. Must be performed before thiopurine therapy is initiated. |
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