N-terminal proBNP Outpatient


Abbrev Code:NTBNP   
Order Code:LAB3640Order Name:N-terminal proBNP Outpatient
Order Instructions:Order ED patients using NTBNPI code.
Synonyms:Brain Natriuretic Peptide; NT-proBNP; NT proBNP; NTBNPI; Pro-BNP
Methodology:Roche: Electrochemiluminescence immunoassay (ECLIA) sandwich immunoassay
Vista/Remisol: Chemiluminescence
CPT Codes: 83880 x1, 83880 x1
Turnaround Time:Performed and reported 24 hours/day.
Associated Links:

Roche Go Live Schedule



Collection Instructions

Specimen:Blood
Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL
Collection Instructions:Chemistry Tests Containers Chart
Causes for Rejection:Hemolyzed samples
Contraindications:Large doses of biotin (10 mg or more per day) may cause clinically significant interference in N-Terminal Pro BNP levels. If interference is suspected, it is strongly recommended that biotin is discontinued for at least one week prior to retesting.


Processing and Shipping

Specimen Processing:Centrifuge and aliquot 1.25 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature to arrive within 72 hours. Alternatively, ship on dry ice..
Stability:3 days at room temperature; 6 days refrigerated; 2 years frozen
Test Performed at or Referral Lab Chemistry  (CSC Maple Grove, Grand Itasca, Northland, Range, Roche-CSC Mpls, Roche-Lakes, Roche-Ridges, Roche-St. John's, Roche-UMMC East, Southdale, UMMC/UMMCH-West Bank)


Interpretive

Reference Range:GH Remisol: All ages: 0-100 pg/mL  
Age Vista
pg/mL
Age Roche
pg/mL
0-2 d 0-13,000   0-2 d 0-13,000  
3-30 d 0-6,500 3-30 d 0-6,500
1-12 mo 0-1000 1-12 mo 0-1,000
1 y 0-680 1 y 0-680
2-5 y 0-330 2-5 y 0-330
6-17 y 0-240 6-17 y 0-240
18-49 y 0-450 18-74 y 0-125
50-75 y 0-900 75 y & older   0-450
76 y & older   0-1,800    


Guidelines:
  • Establishing a baseline value for each individual patient is useful for future follow-up.
  • The Outpatient (non-acute) reference range for ruling out CHF is:
Outpatient (non-acute)   pg/mL  
18-74 y 0-125
75 y & older 0-450
Use:B-Type Natriuretic Peptide (BNP) protein is classed as a cardiac neurohormone and originates from the myocytes of the atrium and ventricles of the heart. It is secreted under conditions of myocardial stretching, volume overload, and increased ventricular filling pressures. ProBNP, the immediate precursor of BNP cleaves to form BNP and NT-proBNP in a 1:1 ratio. NT-proBNP concentrations are higher because the half-life is one to two hours, compared to 22 minutes for BNP. NT-proBNP is used to differentiate heart failure from pulmonary disease in patient presenting with symptoms of dyspnea and shortness of breath. Marked elevations of NT-proBNP may be observed in states other than left ventricular congestive heart failure, including: acute coronary syndromes, right heart strain/failure (including pulmonary embolism and cor pulmonale), critical illness, renal failure, as well as advanced age. Falsely low NT-proBNP in congestive heart failure patients may be observed with increasing body mass index.


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