Cyclosporine Area Under the Curve
| Sunquest Code: | CYAUC | ||
| Epic Code: | LAB3050 | Epic Name: | Cyclosporine AUC Calculation |
| Synonyms: | Cyclosporine AUC | ||
| Methodology: | Liquid chromatography/tandem mass spectrometry | ||
| Turnaround Time: | Performed daily; results are reported the next day. | ||
| Special Instructions: | Collect drug levels at baseline, 2 hours, 3 hours and 4 hours post dose. Order as individual levels and send to laboratory immediately following collection. Only order one CYAUC (area under the curve) calculation per patient. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 1.2 mL |
| Container: | Purple (EDTA) (Green (lithium heparin, no gel), Green (sodium heparin, no gel)) |
| Collection Instructions: | Collect levels at baseline, 2 hours, 3 hours and 4 hours post dose. |
| Causes for Rejection: | Collected in gel tube; clotted specimen. |
Processing and Shipping
| Specimen Processing: | Whole blood. Do not process. Store in refrigerator. |
| Shipping Instructions: | Ship at room temperature. |
| Stability: | Specimens are stable refrigerated or at room temperature for at least two weeks. |
| Test Performed at or Referral Lab | Drug Analysis (UMMC-East Bank) |
Interpretive
| Therapeutic Range: | 4000-6000 ug*h/L |
| Use: | Pharmacokinetics of cyclosporine. |
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