N-terminal proBNP for Inpatients and ED Patients
| Abbrev Code: | NTBNPI | ||
| Order Code: | LAB106 | Order Name: | NT PROBNP Inpatient |
| Synonyms: | NT-proBNP; Brain natriuretic peptide | ||
| Methodology: | Sandwich immunoassay | ||
| CPT Codes: | 83880 x1, 83880 x1 | ||
| Turnaround Time: | Performed and reported 24 hours/day. | ||
| Associated Links: | |||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL |
| Container: | Green (lithium heparin, gel) Alternate Containers: Green (lithium heparin, no gel), Red (no gel), Red (gel) |
| Causes for Rejection: | Hemolyzed samples. |
| Contraindications: | Large doses of biotin (10 mg or more per day) may cause clinically significant interference in N-Terminal pro brain natriuretic peptide levels. If interference is suspected, it is strongly recommended that biotin is discontinued for at least one week prior to retesting. |
Processing and Shipping
| Specimen Processing: | Centrifuge and aliquot 1.25 mL, 0.2 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature to arrive within 72 hours. Alternatively, ship on dry ice. |
| Stability: | 3 days at room temperature; 6 days refrigerated; 2 years frozen. |
| Test Performed at or Referral Lab | Chemistry (Roche-CSC Mpls, Roche-Grand Itasca, Roche-Lakes, Roche-Northland, Roche-Range, Roche-Ridges, Roche-Southdale, Roche-St. John's, Roche-UMMC East, Roche-UMMC West) |
Interpretive
| Reference Range: |
Guidelines:
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| Use: | B-Type Natriuretic Peptide (BNP) protein is classed as a cardiac neurohormone and originates from the myocytes of the atrium and ventricles of the heart. It is secreted under conditions of myocardial stretching, volume overload, and increased ventricular filling pressures. ProBNP, the immediate precursor of BNP cleaves to form BNP and NT-proBNP in a 1:1 ratio. NT-proBNP concentrations are higher because the half-life is one to two hours, compared to 22 minutes for BNP. NT-proBNP is used to differentiate heart failure from pulmonary disease in patient presenting with symptoms of dyspnea and shortness of breath. Marked elevations of NT-proBNP may be observed in states other than left ventricular congestive heart failure, including: acute coronary syndromes, right heart strain/failure (including pulmonary embolism and cor pulmonale), critical illness, renal failure, as well as advanced age. Falsely low NT-proBNP in congestive heart failure patients may be observed with increasing body mass index. |
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