Mycophenolic Acid, Free Area Under the Curve Study
| Sunquest Code: | FMPAUC | ||
| Epic Code: | LAB3243 | Epic Name: | MPA AUC Free Study |
| Synonyms: | Cellcept; MMF; Mofetil; Myfortic, Free; AUC, Timed Study | ||
| Methodology: | Ultrafiltration, liquid chromatography/tandem mass spectrometry | ||
| Test Includes: | Free mycophenolic acid (MPA), Time and AUC calculation. | ||
| Turnaround Time: | Performed twice/week; results are reported the next day. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 3 mL |
| Minimum\Peds Volume: | 1.2 mL |
| Container: | Purple (EDTA) |
| Collection Instructions: | Collect samples prior to dose and at times 2, 4, 6, and 8 hours post dose. |
| Causes for Rejection: | Sample not separated from cells within 2 hours of collection. |
Processing and Shipping
| Specimen Processing: | Within 2 hours, centrifuge and aliquot all of the plasma sample, 0.5 mL minimum. Store in freezer. Whole blood or plasma samples are stable for 4 hours at room temperature, or for 8 hours if refrigerated. |
| Shipping Instructions: | Ship on dry ice. |
| Test Performed at or Referral Lab | Drug Analysis (UMMC-East Bank) |
Interpretive
| Therapeutic Range: | 0-12 year: Free MPA AUC 200-400 ug*hr/L; 12 y and older: Free MPA AUC 150-500 ug*hr/L, >600 ug*hr/L for HSCT patients |
| Use: | Therapeutic drug monitoring and to assess toxicity and available free drug concentration. |
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