Mycophenolic Acid, Free Area Under the Curve Study

Abbrev Code:FMPAUC   
Order Code:LAB3243Order Name:MPA AUC Free Study
Synonyms:Cellcept; MMF; Mofetil; Myfortic, Free; AUC, Timed Study
Methodology:Ultrafiltration, liquid chromatography/tandem mass spectrometry
CPT Codes: 80180 x1
Test Includes:Free mycophenolic acid (MPA), Time and AUC calculation.
Turnaround Time:Performed as received Monday-Friday; results are reported the next day.

Collection Instructions

Optimal Volume:3 mL
Minimum\Peds Volume:1.2 mL
Container:Purple (EDTA)
Collection Instructions:Collect samples prior to dose and at times 2, 4, 6, and 8 hours post dose.
Causes for Rejection:Sample not separated from cells within 2 hours of collection.

Processing and Shipping

Specimen Processing:Within 2 hours, centrifuge and aliquot all of the plasma sample, 0.5 mL minimum. Store in freezer. Whole blood or plasma samples are stable for 4 hours at room temperature, or for 8 hours if refrigerated.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab UM Special Drug/Biochemical Genetics (Y)  (UMMC East Bank)


Therapeutic Range:0-12 year: Free MPA AUC 200-400 ug*hr/L; 12 y and older: Free MPA AUC 150-500 ug*hr/L, >600 ug*hr/L for HSCT patients
Use:Therapeutic drug monitoring and to assess toxicity and available free drug concentration.

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