Neuronal Nuclear Antibodies IgG Immunoblot
| Sunquest Code: | ARMISC | ||
| Epic Code: | LAB4909 | Epic Name: | Neuronal Nuclear Ab IgG Immunoblot |
| Synonyms: | Anti Hu, Anti Ri and Anti Yo; Anti-Hu, Anti-Ri and Anti-Yo; Anti Neuronal; Antineuronal | ||
| Methodology: | Immunoblot | ||
| Test Includes: | Anti Hu, Anti Ri and Anti-Yo and Anti Tr/DNER | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-4 days. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2 mL |
| Minimum\Peds Volume: | 0.8 mL |
| Container: | Red or gold (gel) (Red (no gel)) |
| Causes for Rejection: | Plasma. Hemolyzed, lipemic or contaminated specimens. |
Processing and Shipping
| Specimen Processing: | Centrifuge within 2 hours of collection and aliquot 1 mL, 0.30 mL minimum. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | After separation from cells: 48 hours at room temperature; 2 weeks refrigerated; 1 year frozen. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 3002917 |
Interpretive
| Reference Range: | Negative |
| Use: | This test detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens.
Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and fallopian tube and with breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr (DNER) is associated with Hodgkin's lymphoma. The presence of one or more of these antibodies supports the clinical diagnosis of PND and leads to a focused search for for the underlying neoplasm. |
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