Neuronal Nuclear Antibodies IgG Immunoblot
Abbrev Code: | ARMISC | ||
Order Code: | LAB4909 | Order Name: | Neuronal Nuclear Ab IgG Immunoblot |
Synonyms: | Anti Hu, Anti Ri and Anti Yo; Anti-Hu, Anti-Ri and Anti-Yo; Anti Neuronal; Antineuronal | ||
Methodology: | Immunoblot | ||
CPT Codes: | 84182 x4 | ||
Test Includes: | Anti Hu, Anti Ri and Anti-Yo and Anti Tr/DNER | ||
Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported within 1-4 days. |
Collection Instructions
Specimen: | Blood |
Optimal Volume: | 2 mL |
Minimum\Peds Volume: | 0.8 mL |
Container: | Red or gold (gel) Alternate Containers: Red (no gel) |
Causes for Rejection: | Plasma. Hemolyzed, lipemic or contaminated specimens. |
Processing and Shipping
Specimen Processing: | Centrifuge within 2 hours of collection and aliquot 1 mL, 0.30 mL minimum. |
Shipping Instructions: | Ship at refrigerated temperature. |
Stability: | After separation from cells: 48 hours at room temperature; 2 weeks refrigerated; 1 year frozen. |
Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
Referral Lab number: | 3002917 |
Interpretive
Reference Range: | Negative |
Use: | This test detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens.
Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small-cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with neuroblastoma in children and fallopian tube and with breast cancer in adults. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr (DNER) is associated with Hodgkin's lymphoma. The presence of one or more of these antibodies supports the clinical diagnosis of PND and leads to a focused search for for the underlying neoplasm. |
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