Gentamicin, Single Daily Dose


Abbrev Code:GENTSD   
Order Code:LAB4569Order Name:Gentamicin Single Dose
Methodology:Roche: CEDIA homogeneous enyzyme immunoassay
Vista: Turbimetric
CPT Codes: 80170 x1, 80170 x1
Turnaround Time:Performed and reported 24 hours/day
Special Instructions:Order when single daily dose is given. Comment last dose information on request. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results.


Collection Instructions

Specimen:Blood
Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL, 0.4 pediatric patients only.
Collection Instructions:Chemistry Tests Containers Chart
  Trough levels: Collect immediately prior to the next dose. Peak levels: Collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function.
Causes for Rejection:Processed >2 hours after collection and patient is receiving beta-lactam antibiotics structurally similar to gentamicin (e.g. netilmicin, sagamicin and sisomicin) or cephalosporin; collection in a gel tube


Processing and Shipping

Specimen Processing:Centrifuge and assay immediately. If assaying is delayed more than 2 hours, then aliquot 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds) and freeze the sample.

If specimen is received >2 hours after collection; check with PCU/Clinic to see if patient is receiving beta-lactam antibiotics or cephalosporins. If so, cancel the test. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results.
Shipping Instructions:Ship at refrigerated temperature.
Stability:7 days refrigerated; 4 weeks frozen.
Test Performed at or Referral Lab Chemistry  (Roche-Lakes, Roche-UMMC East, Southdale, UMMC/UMMCH-West Bank)


Interpretive

Critical Range:Single daily dosing (Note: mg/L - ug/mL)
Roche: >24 ug/mL
Vista: Greater than 35 mg/L
Therapeutic Range:Vista and Roche:
Trough: Approaching zero.
Peak: 17-24 mg/L or ug/mL
Use:Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult: less than 30 y); 3-6 h (adult: 30 y or greater); 4-8 h (neonate).


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