Gentamicin, Single Daily Dose
| Sunquest Code: | GENTSD | ||
| Epic Code: | LAB4569 | Epic Name: | Gentamicin Single Dose |
| Methodology: | Turbidimetric rate | ||
| Turnaround Time: | Performed and reported 24 hours/day | ||
| Special Instructions: | Order when single daily dose is given. Comment last dose information on request form. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL, 0.4 pediatric patients only. |
| Container: | Red (no gel), St Johns/St Joseph/Woodwinds-Green (lithium heparin, no gel) (Green (lithium heparin, no gel), St Johns/St Joseph/Woodwinds - Red (no gel)) |
| Collection Instructions: | Trough levels: Collect immediately prior to the next dose. Peak levels: Collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function. |
| Causes for Rejection: | Processed >2 hours after collection and patient is receiving beta-lactam antibiotics structurally similar to gentamicin (e.g. netilmicin, sagamicin and sisomicin) or cephalosporin; collection in a gel tube |
Processing and Shipping
| Specimen Processing: | Centrifuge and assay immediately. If assaying is delayed more than 2 hours, then aliquot 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds) and freeze the sample. |
| Shipping Instructions: | Ship on dry ice. |
| Stability: | If specimen is received >2 hrs after collection, check with PCU/Clinic to see if patient is receiving beta-lactam antibiotics or cephalosporins. If so, cancel the test. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results. |
| Test Performed at or Referral Lab | Chemistry (UMMC-East Bank, Lakes, Northland, Southdale, UMMC/UMMCH-West Bank) |
Interpretive
| Critical Range: | Greater than 35 mg/L for single daily dosing. |
| Therapeutic Range: | Trough: Approaching zero. Peak: 17-24 mg/L |
| Use: | Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult: less than 30 y); 3-6 h (adult: 30 y or greater); 4-8 h (neonate). |
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