Tobramycin, Single Daily Dose
| Abbrev Code: | TOBSD | ||
| Order Code: | LAB4579 | Order Name: | Tobramycin Single Daily Dose |
| Synonyms: | Nebcin | ||
| Methodology: | Homogeneous enzyme immunoassay | ||
| CPT Codes: | 80200 x1, 80200 x1 | ||
| Turnaround Time: | Performed and reported 24 hours/day. | ||
| Special Instructions: | Order when single daily dose given. Comment last dose information on request. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results. | ||
Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 2.5 mL |
| Minimum\Peds Volume: | 0.6 mL; pediatric patients only: 0.4 mL |
| Container: | Red (no gel) Alternate Containers: Purple (EDTA) |
| Collection Instructions: | Trough levels: Collect immediately prior to next dose. Peak levels: Collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function. |
| Causes for Rejection: | Processed >2 hours after collection. Sample not analyzed or frozen within 4 hours. Collection in a gel tube. |
Processing and Shipping
| Specimen Processing: | Process within 2 hours. centrifuge and aliquot 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds). If assaying is delayed more than 4 hours, then aliquot and freeze the sample. Cancel if patient is receiving beta-lactam antibiotics or cephalosporins. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results. |
| Shipping Instructions: | Ship refrigerated. |
| Stability: | 3 days refrigerated; 1 month frozen |
| Test Performed at or Referral Lab | Chemistry (Roche-UMMC East) |
Interpretive
| Critical Range: | >20 mg/L for single daily dosing
Note: mg/L = ug/mL |
| Therapeutic Range: | Trough: 0.5-2.0 ug/mL
Peak: 6-10 ug/mL |
| Use: | Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult: less than 30 y); 3-6 h (adult: 30 y or greater); 4-8 h (neonate). |
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