Tobramycin, Single Daily Dose


Abbrev Code:TOBSD   
Order Code:LAB4579Order Name:Tobramycin Single Daily Dose
Synonyms:Nebcin
Methodology:Roche: Homogeneous enzyme immunoassay
Vista: Turbidmetric rate
CPT Codes: 80200 x1, 80200 x1
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:Order when single daily dose given. Comment last dose information on request. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results.


Collection Instructions

Specimen:Blood
Optimal Volume:2.5 mL
Minimum\Peds Volume:0.6 mL; pediatric patients only: 0.4 mL in green (lithium heparin, no gel)
Collection Instructions:Chemistry Tests Containers Chart
Trough levels: Collect immediately prior to next dose. Peak levels: Collect 60 minutes after the end of IV infusion; 1-2 hours if decreased renal function.
Causes for Rejection:Processed >2 hours after collection. Sample not analyzed or frozen within 4 hours. Collection in a gel tube.


Processing and Shipping

Specimen Processing:Process within 2 hours. centrifuge and aliquot 1.25 mL, 0.2 mL minimum (adult) 0.1 mL minimum (peds). If assaying is delayed more than 4 hours, then aliquot and freeze the sample. Cancel if patient is receiving beta-lactam antibiotics or cephalosporins. Beta-lactam antibiotics and cephalosporins will inactivate aminoglycosides causing falsely low results.
Shipping Instructions:Ship refrigerated.
Stability:Roche: 3 days refrigerated; 1 month frozen
Vista: 4 hours at room or refrigerated temperature; 1 month frozen.
Test Performed at or Referral Lab Chemistry  (Lakes, Roche-UMMC East, Southdale, UMMC/UMMCH-West Bank)


Interpretive

Critical Range:
Vista >35 ug/mL for single daily dosing
Roche >20 mg/L for single daily dosing
Note: mg/L = ug/mL
Therapeutic Range:Roche: Trough 0.5-2.0 ug/mL; Peak 6-10 ug/mL
Vista: Trough: Approaching zero; Peak: 17-24 mg/L
Use:Monitor therapeutic dosing and evaluate toxicity. Half-life is 1.5-3 h (adult: less than 30 y); 3-6 h (adult: 30 y or greater); 4-8 h (neonate).


Click HERE to Report test errors or omissions.
*If no email program is associated with this computer, please contact:
systemlabguide@fairview.org for TestID: 4405"