Immunoglobulin Total Light Chains, Urine
| Sunquest Code: | TLCU | ||
| Epic Code: | LAB5595 | Epic Name: | Total Light Chain UR |
| Synonyms: | Urine Light Chains; Light Chains, Kappa and Lambda; Immunoglobulin Light Chains | ||
| Methodology: | Nephelometry | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Fri; results are reported within 3-7 days. | ||
| Compliance: | This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared by the U.S. Food and Drug Administration. |
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Collection Instructions
| Specimen: | Urine, 24 hour collection or random collection |
| Optimal Volume: | Submit entire volume; analysis requires 0.5 mL |
| Container: | 3 L plastic jug (Plastic leakproof container, sterile) |
| Collection Instructions: | Refrigerate during collection. |
Processing and Shipping
| Specimen Processing: | Mix collection well before aliquot is taken. Aliquot 1 mL, 0.5 mL minimum. Store in refrigerator. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Test Performed at or Referral Lab | Lab Sendouts (Mayo) |
| Referral Lab number: | TLCU |
Interpretive
| Reference Range: | Kappa total light chain: <0.9 mg/dL Lambda total light chain: <0.7 mg/dL Kappa/lambda ratio: 0.7-6.2 |
| Use: | A kappa/lambda (K/L) ratio of >6.2 suggests the presence of monoclonal kappa light chains. A K/L ratio of <0.7 suggests the presence of monoclonal lambda light chains. In 24 hour specimens, a >25% increase in concentration suggests progression or relapse; a >25% decrease suggests treatment response. Increased kappa and/or lambda light chains may be seen in benign (polyclonal) and neoplastic (monoclonal) disorders. |
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