Celiac (Gluten) Antibody Panel
| Abbrev Code: | CGL | ||
| Order Code: | LAB1082 | Order Name: | Celiac (Gluten) Antibody Panel |
| Synonyms: | LHE LAB822 | ||
| Methodology: | IgA: Immunoturbidmetry, TTG and Gliadin: FEIA (by ImmunoCAP) | ||
| CPT Codes: | 82784 x1, 82784 x1, 83516 x2, 83516 x2, 83516 x2, 83516 x2, 83516 x4 | ||
| Test Includes: | IgA (IGA); Deaminated Gliadin Antibodies, IgA and IgG (DGPABY); Tissue Transglutamniase Antibodies, IgA and IgG (TTGABY) | ||
| Turnaround Time: | Performed Mon-Fri; results are reported within 1-3 days. | ||
| Special Instructions: | IgA is performed at UM Speciality Core/Prot/Endo (Optilite C)
TTG and Gliadin are performed at UM Specialty Core/Prot/Endo (Phadia ELiA G) |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 4 mL |
| Minimum\Peds Volume: | 2.4 mL |
| Container: | Red or gold (gel) Alternate Containers: Purple (EDTA), Red (no gel) |
| Causes for Rejection: | Hemolyzed, lipemic or microbially contaminated specimens. Samples not separated from cells within 2 hours of collection. |
Processing and Shipping
| Specimen Processing: | Within 2 hours of collection centrifuge and aliquot 1.3 mL, 0.6 mL minimum. Store at refrigerated temperature. |
| Shipping Instructions: | Ship at refrigerated temperature. |
| Stability: | After separation from cells: 8 days refrigerated; indefinitely frozen. |
Interpretive
| Reference Range: | Refer to individual test entries for IgA, TTGABY and DGPABY. |
| Use: | Celiac disease is an autoimmune digestive disease characterized by a permanent intolerance to gluten. Gluten triggers an inflammatory immune repsonse in the mucosa of the small intestine. A gluten-free diet can completely stop the immune response and the small intestine can repair itself. The antibody levels decline and eventually disappear. Re-introduction of gluten retriggers the response. Serological screening offers a minimally invasive option for rapid identification of patients likely to have celiac disease and to select those who should be subjected to biopsy. Various autoantibodies are produced by patients. TTG (tissue transglutaminase) is the primary autoantigen recognized by endomysial antibodies in patients with celiac disease and may be the most useful first-level screening test for celiac disease. IgA antibodfies usually predominate, but IgG antibodies may also be produced. |
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