Anti-Mullerian Hormone

Abbrev Code:MULHOR   
Order Code:LAB5899Order Name:Anti-Mullerian Hormone
Synonyms:Antimullerian Hormone; AMH
Methodology:Monoclonal sandwich assay
CPT Codes: 83520 x1, 83520 x1
Turnaround Time:Performed and reported 24 hours/day.

Collection Instructions

Optimal Volume:1.2 mL
Minimum\Peds Volume:0.6 mL
Container:Green (lithium heparin, gel)
Alternate Containers: Green (lithium heparin, no gel), Green (lithium heparin, gel) on ICE, Red (no gel), Red or gold (gel)
Collection Instructions:Samples for AMH levels should be collected on days 2-4 of the menstrual cycle.
Causes for Rejection:Hemolyzed or lipemic specimens.

Processing and Shipping

Specimen Processing:Centrifuge within 2 hours and aliquot ASAP 0.5 mL, 0.2 mL minimum.
Shipping Instructions:Ship on dry ice.
Stability:3 days at room temperature; 5 days refrigerated; 6 months frozen. Freeze only once.
Test Performed at or Referral Lab Chemistry  (Roche-UMMC East)


Reference Range:
Female ng/mL
0-2 y 0.11-4.20
3-6 y 0.21-4.90
7-11 y 0.36-5.90
12-14 y 0.49-6.90
15-19 y 0.62-7.80
20-24 y 1.2-12.00
25-29 y 0.89-9.90
30-34 y 0.58-8.10
35-39 y 0.15-7.50
40-44 y 0.03-5.50
45-49 y <2.60
50-54 y <0.88
55 y & up <0.03
Male ng/mL
0-1 y 18.00-283.00
2-11 y 8.9-109.00
12 y & up <13.00
Unspecified ng/mL
0-1 y 0.11-283.00
2 y 0.11-109.00
3-6 y 0.21-109.00
7-11 y 0.36-109.00
12 y & up <13.00
Use:AMH is used for the assessment of the ovarian reserve in women presenting to fertility clinics. This system is intended to distinguish between women presenting with AFC (antral follicle count) values > 15 (high ovarian reserve) and women with AFC values ≤ 15 (normal or diminished ovarian reserve). This system is intended to be used for assessing the ovarian reserve in conjunction with other clinical and laboratory findings before starting any fertility therapy. It is not intended to be used for monitoring of women undergoing controlled ovarian stimulation in an Assisted Reproduction Technology program.

Serum AMH levels have been shown to be relatively stable during the menstrual cycle with substantial fluctuations being observed in younger women.  AMH levels further demonstrate lower intra- and inter-cyclic variation than baseline FSH. Serum AMH levels decrease significantly during the use of combined contraceptives. Measurement of serum AMH is clinically used for assessment of ovarian reserve reflecting the number of antral and pre-antral follicles, the so-called antral follicle count (AFC).

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