Cytomegalovirus Antiviral Drug Resistance
| Sunquest Code: | CMVRES | ||
| Epic Code: | LAB6017 | Epic Name: | CMV Drug Resistance |
| Synonyms: | CMV | ||
| Methodology: | Polymerase chain reaction (PCR)/Sequencing | ||
| Turnaround Time: | Specimens are sent to reference laboratory Mon-Sat; results are reported within 2-3 days. | ||
| Special Instructions: | Please submit most recent viral load and test date, if available. This test may be unsuccessful if the plasma CMV DNA viral load is less than 1,500 CMV DNA copies per mL of plasma. | ||
| Compliance: | This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes. |
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Collection Instructions
| Specimen: | Blood |
| Optimal Volume: | 8 mL |
| Minimum\Peds Volume: | 3.2 mL |
| Container: | Purple (EDTA) |
| Causes for Rejection: | Serum or heparinized plasma |
Processing and Shipping
| Specimen Processing: | Within 8 hour of collection, centrifuge and aliquot 4 mL, 1.5 mL minimum. Separate specimens must be submitted when multiple tests are ordered. Store in freezer. |
| Shipping Instructions: | Ship on dry ice. |
| Test Performed at or Referral Lab | Lab Sendouts (ARUP) |
| Referral Lab number: | 2004760 |
Interpretive
| Reference Range: | Codons 457-630 of the UL97 gene and codons 393-1000 of the UL54 gene are sequenced. Mutations associated with resistance to ganciclovir, cidofovir and foscarnet are reported. Mutations in viral sub-populations below 20 percent of total may not be detected. |
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